4,4'-Diaminodiphenylamine

INCI: 4,4'-DIAMINODIPHENYLAMINE

CAS Number
537-65-5
Function
Hair Dye (oxidative)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Technically permissible under coal tar hair dye exemption (FD&C Act ยง601(a)) with mandatory caution labeling and patch test instructions; not an approved color additive

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Aromatic amine structure with potential mutagen and carcinogen concerns; banned in EU hair dye products.

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Concern Level: High

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4,4'-Diaminodiphenylamine safe in cosmetics?

Aromatic amine structure with potential mutagen and carcinogen concerns; banned in EU hair dye products. The EU classifies 4,4'-Diaminodiphenylamine as "prohibited". Safety rating: POOR.

Is 4,4'-Diaminodiphenylamine allowed in the EU?

4,4'-Diaminodiphenylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4,4'-Diaminodiphenylamine do in cosmetics?

4,4'-Diaminodiphenylamine functions as: Hair Dye (oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 537-65-5.

What is the Margin of Safety for 4,4'-Diaminodiphenylamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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