Moderate Cosmetic Ingredient

4-Nitro-O-Phenylenediamine Sulfate

INCI: 4-NITRO-O-PHENYLENEDIAMINE SULFATE

CAS Number
68239-82-7
Function
Oxidative hair dye (salt form of parent compound 4-NOPD, CAS 99-56-9)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted; covered under same CIR assessment as parent compound

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Prohibited in EU due to in vitro mutagenicity and liver hypertrophy; extreme sensitization potency observed. Permitted in US under CIR assessment of parent compound.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 4-Nitro-O-Phenylenediamine Sulfate safe in cosmetics?

Prohibited in EU due to in vitro mutagenicity and liver hypertrophy; extreme sensitization potency observed. Permitted in US under CIR assessment of parent compound. The EU classifies 4-Nitro-O-Phenylenediamine Sulfate as "prohibited". Safety rating: MODERATE.

Is 4-Nitro-O-Phenylenediamine Sulfate allowed in the EU?

4-Nitro-O-Phenylenediamine Sulfate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Nitro-O-Phenylenediamine Sulfate do in cosmetics?

4-Nitro-O-Phenylenediamine Sulfate functions as: Oxidative hair dye (salt form of parent compound 4-NOPD, CAS 99-56-9). It is classified as a cosmetic ingredient in our database. CAS number: 68239-82-7.

What is the Margin of Safety for 4-Nitro-O-Phenylenediamine Sulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 4-Nitro-O-Phenylenediamine Sulfate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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