Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Blue 74. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2400 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1350 mg/kg bw/day | oral | swine | Subchronic | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
Expert Verdict
Long food-use history supports safety profile; rare anaphylactoid reactions possible at high systemic exposure.
Regulatory Flags
Frequently Asked Questions
Is Acid Blue 74 safe in cosmetics?
Long food-use history supports safety profile; rare anaphylactoid reactions possible at high systemic exposure. The EU classifies Acid Blue 74 as "prohibited". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Acid Blue 74 allowed in the EU?
Acid Blue 74 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Blue 74 do in cosmetics?
Acid Blue 74 functions as: Colorant, Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 860-22-0.
What is the Margin of Safety for Acid Blue 74?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acid Blue 74?
The NOAEL (No Observed Adverse Effect Level) for Acid Blue 74 is 250 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Acid Blue 74 compliance across multiple jurisdictions:
Related Ingredients
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