Regulatory Status
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Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Dermal Penetration Profile
Skin absorption and penetration characteristics of Allantoin, relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
CIR safe as used (2010). MoS approximately 21,846 (200x SCCS minimum). Non-sensitizing with HRIPT n=600+. Comedogenicity 0. US OTC dual status: 0.5-2% as skin protectant drug (21 CFR 347). DNEL 284 mg/kg/day (REACH). Ames negative. COSMOS approved nature-identical. Not listed in EU or global Annexes. Readily biodegradable.
Regulatory Flags
Frequently Asked Questions
Is Allantoin safe in cosmetics?
CIR safe as used (2010). MoS approximately 21,846 (200x SCCS minimum). Non-sensitizing with HRIPT n=600+. Comedogenicity 0. US OTC dual status: 0.5-2% as skin protectant drug (21 CFR 347). DNEL 284 mg/kg/day (REACH). Ames negative. COSMOS approved nature-identical. Not listed in EU or global Annexes. Readily biodegradable. The EU classifies Allantoin as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.
Is Allantoin allowed in the EU?
Allantoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allantoin do in cosmetics?
Allantoin functions as: Skin conditioner, keratolytic, anti-irritant, wound-healing agent; promotes orderly cell turnover; stimulates fibroblast proliferation; typical use 0.5–2%. It is classified as a Active Ingredient in our database. CAS number: 97-59-6.
What is the Margin of Safety for Allantoin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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