Is Uplevity (Acetyl Tetrapeptide-2) safe in cosmetics?
Uplevity (Acetyl Tetrapeptide-2) has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
GOOD
Active Ingredient
Uplevity (Acetyl Tetrapeptide-2)
INCI: ACETYL TETRAPEPTIDE-2
Uplevity (Acetyl Tetrapeptide-2) (CAS 757942-88-4) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted, max 21.7%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 757942-88-4 →
Function
Peptide / Anti-aging active
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(3S)-3-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
InChIKey
ITIMHIATVYROGF-XWUOBKMESA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
21.7%
US US Status
restricted
US Notes
CIR Safety Assessment of related peptides - CIR Expert Panel (2018), International Journal of Toxicology, covers Tripeptide-1/Hexapeptide-12 families but not Acetyl Tetrapeptide-2 directly
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Uplevity (Acetyl Tetrapeptide-2).
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Uplevity (Acetyl Tetrapeptide-2) — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is Uplevity (Acetyl Tetrapeptide-2) allowed in the EU?
Uplevity (Acetyl Tetrapeptide-2) EU regulatory status: permitted. Maximum allowed concentration: 21.7%. This is based on EU Regulation 1223/2009 and its amendments.
What does Uplevity (Acetyl Tetrapeptide-2) do in cosmetics?
Uplevity (Acetyl Tetrapeptide-2) functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 757942-88-4.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Acetyl Tetrapeptide-2
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