Is Uplevity (Acetyl Tetrapeptide-2) safe in cosmetics?
Uplevity (Acetyl Tetrapeptide-2) has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Active Ingredient
Uplevity (Acetyl Tetrapeptide-2)
INCI: ACETYL TETRAPEPTIDE-2
Uplevity (Acetyl Tetrapeptide-2) (CAS 757942-88-4) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted, max 21.7%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 757942-88-4 →
Auto-generated CPSR Part A draft with source citations
Function
Peptide / Anti-aging active
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(3S)-3-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
InChIKey
ITIMHIATVYROGF-XWUOBKMESA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
21.7%
US US Status
restricted
US Notes
CIR Safety Assessment of related peptides - CIR Expert Panel (2018), International Journal of Toxicology, covers Tripeptide-1/Hexapeptide-12 families but not Acetyl Tetrapeptide-2 directly
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Uplevity (Acetyl Tetrapeptide-2).
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "firming, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "757942-88-4", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
depigmentation
{"cas_number": "not established", "ingredient_class": "anti_inflammatory_brightener", "primary_mechanism_of_action": "Thymus peptide reducing inflammation-induced pigmentation", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_cli…
self_tanning
{"cas_number": "proprietary", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_releas…
synergy
{"inci_name_2": "Resveratrol", "synergy_type": "antioxidant-synergy", "synergy_description": "Thymic peptide with sirtuin activator for longevity", "combined_benefit": "Enhanced cellular longevity, immune support, comprehensive anti-aging", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Tetrapeptide-2 mimics thymulin supporting immunity; resveratrol activates sirtuins", "optimal_ratio": "1…
Expert Verdict
Expert safety assessment and concern-level summary for Uplevity (Acetyl Tetrapeptide-2).
Frequently Asked Questions
Is Uplevity (Acetyl Tetrapeptide-2) allowed in the EU?
Uplevity (Acetyl Tetrapeptide-2) EU regulatory status: permitted. Maximum allowed concentration: 21.7%. This is based on EU Regulation 1223/2009 and its amendments.
What does Uplevity (Acetyl Tetrapeptide-2) do in cosmetics?
Uplevity (Acetyl Tetrapeptide-2) functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 757942-88-4.
Compliance Tools
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MoS Calculator
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Chemical family
Softener and conditioner
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