Moderate Active Ingredient Dermal Penetration

Hexapeptide-11 (Myristoyl Hexapeptide-16)

INCI: HEXAPEPTIDE-11

CAS Number
161258-30-6
Function
Peptide / Anti-aging active
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes CIR Safety Assessment: No dedicated report. OTC drug classification applies.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Hexapeptide-11 (Myristoyl Hexapeptide-16), relevant to systemic exposure and MoS calculations.

Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
673.8 Da
Log P
-0.8
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Cosmetic Science

Expert Verdict

Insufficient safety data available for Hexapeptide-11. Further assessment recommended before widespread use.

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Concern Level: Moderate

Frequently Asked Questions

Is Hexapeptide-11 (Myristoyl Hexapeptide-16) safe in cosmetics?

Insufficient safety data available for Hexapeptide-11. Further assessment recommended before widespread use. The EU classifies Hexapeptide-11 (Myristoyl Hexapeptide-16) as "permitted". Safety rating: MODERATE.

Is Hexapeptide-11 (Myristoyl Hexapeptide-16) allowed in the EU?

Hexapeptide-11 (Myristoyl Hexapeptide-16) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-11 (Myristoyl Hexapeptide-16) do in cosmetics?

Hexapeptide-11 (Myristoyl Hexapeptide-16) functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 161258-30-6.

What is the Margin of Safety for Hexapeptide-11 (Myristoyl Hexapeptide-16)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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