Allantoin Glycyrrhetinic Acid

INCI: ALLANTOIN GLYCYRRHETINIC ACID

CAS Number
4572-09-2
Function
Skin Conditioning (miscellaneous)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Expert Panel concluded safe (2010); glycyrrhetinic acid independently reviewed and found safe at โ‰ค2% concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Reported use in only 6 cosmetic products; no concentration-of-use data reported to CTFA. Glycyrrhetinic acid at high systemic doses can cause pseudoaldosteronism, but cosmetic exposure levels are far below concern thresholds.

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Concern Level: Low

Frequently Asked Questions

Is Allantoin Glycyrrhetinic Acid safe in cosmetics?

Reported use in only 6 cosmetic products; no concentration-of-use data reported to CTFA. Glycyrrhetinic acid at high systemic doses can cause pseudoaldosteronism, but cosmetic exposure levels are far below concern thresholds. The EU classifies Allantoin Glycyrrhetinic Acid as "permitted". Safety rating: GOOD.

Is Allantoin Glycyrrhetinic Acid allowed in the EU?

Allantoin Glycyrrhetinic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Allantoin Glycyrrhetinic Acid do in cosmetics?

Allantoin Glycyrrhetinic Acid functions as: Skin Conditioning (miscellaneous). It is classified as a cosmetic ingredient in our database. CAS number: 4572-09-2.

What is the Margin of Safety for Allantoin Glycyrrhetinic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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