Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Allium Sativum Bulb Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 67 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | 75 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 100 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 67 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 5 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 4 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| dose_tested | 75 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Diallyl disulfide is a documented contact allergen with positive patch test rates in occupational studies; can cause chemical burns at undiluted concentrations and exhibits dose-dependent irritation.
Regulatory Flags
Frequently Asked Questions
Is Allium Sativum Bulb Oil safe in cosmetics?
Diallyl disulfide is a documented contact allergen with positive patch test rates in occupational studies; can cause chemical burns at undiluted concentrations and exhibits dose-dependent irritation. The EU classifies Allium Sativum Bulb Oil as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Allium Sativum Bulb Oil allowed in the EU?
Allium Sativum Bulb Oil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allium Sativum Bulb Oil do in cosmetics?
Allium Sativum Bulb Oil functions as: Masking, Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 8000-78-0.
What is the Margin of Safety for Allium Sativum Bulb Oil?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Allium Sativum Bulb Oil?
The NOAEL (No Observed Adverse Effect Level) for Allium Sativum Bulb Oil is 100 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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