Is Ammonium Carbamate safe in cosmetics?
Ammonium Carbamate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ammonium Carbamate
Also known as: Carbamic acid, monoammonium salt, Ammonium aminoformate, "Anhydride" of ammonium carbonate, EINECS 214-185-2, UNII-I2W9615SWP (+1 more)
INCI: AMMONIUM CARBAMATE
Ammonium Carbamate (CAS 1111-78-0) is a cosmetic cosmetic ingredient functioning as Buffering. NOAEL 474 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1111-78-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ammonium Carbamate is classified GHS Danger (H302, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR reviewed as a component of Ammonium Carbonate — safe as used when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonium Carbamate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ammonium Carbamate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Ammonium Carbamate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ammonium Carbamate by CAS number or substance name.
Studies
18
Lowest NOAEL
1 mg/kg bw/day
Highest NOAEL
1104.6 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Carbamic acid, monoammonium salt
Ammonium aminoformate
"Anhydride" of ammonium carbonate
EINECS 214-185-2
UNII-I2W9615SWP
Carbamic acid, ammonium salt (1:1)
Chemical Function
pH regulating agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3560381
Frequently Asked Questions
Is Ammonium Carbamate allowed in the EU?
Ammonium Carbamate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Carbamate do in cosmetics?
Ammonium Carbamate functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 1111-78-0.
Is Ammonium Carbamate used outside cosmetics?
Ammonium Carbamate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ammonium Carbamate have different safety status in cosmetics vs industrial chemicals?
Ammonium Carbamate is classified GHS Danger (H302, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Ammonium Carbamate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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