Moderate Cosmetic Ingredient NOAEL Data

Ammonium Iodide

INCI: AMMONIUM IODIDE

CAS Number
12027-06-4
Function
No standard INCI cosmetic function assigned; historically pharmaceutical/topical
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” No specific FDA cosmetic restriction; very limited cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Ammonium Iodide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 0.01 mg/kg bw/day oral code:3544 oral REACH
NOAEL 10 mg/kg bw/day oral rat oral REACH
NOAEL 684 mg/kg bw/day oral rat oral REACH
NOAEL >10 mg/kg bw/day other rat oral REACH

Expert Verdict

Thyroid disruption risk with systemic absorption; iododerma/halogenoderma risk; not recommended for leave-on products without dedicated safety assessment; essentially pharmaceutical, not cosmetic

โš ๏ธ
Concern Level: High

Frequently Asked Questions

Is Ammonium Iodide safe in cosmetics?

Thyroid disruption risk with systemic absorption; iododerma/halogenoderma risk; not recommended for leave-on products without dedicated safety assessment; essentially pharmaceutical, not cosmetic The EU classifies Ammonium Iodide as "prohibited". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Ammonium Iodide allowed in the EU?

Ammonium Iodide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonium Iodide do in cosmetics?

Ammonium Iodide functions as: No standard INCI cosmetic function assigned; historically pharmaceutical/topical. It is classified as a cosmetic ingredient in our database. CAS number: 12027-06-4.

What is the Margin of Safety for Ammonium Iodide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ammonium Iodide?

The NOAEL (No Observed Adverse Effect Level) for Ammonium Iodide is 0.01 mg/kg bw/day based on a oral study via oral route in code:3544. A total of 4 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is Ammonium Iodide in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ammonium Iodide in your formulation.