Is Ammonium Sulfate safe in cosmetics?
Ammonium Sulfate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 7 toxicological study endpoint(s) are available in our database.
Ammonium Sulfate
Also known as: Sulfuric acid diammonium salt, Actamaster, Caswell No. 048, EINECS 231-984-1, EPA Pesticide Chemical Code 005601 (+6 more)
INCI: AMMONIUM SULFATE
Ammonium Sulfate (CAS 7783-20-2) is a cosmetic cosmetic ingredient functioning as Buffering, viscosity controlling. NOAEL 256 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Buffering, viscosity controlling
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; FDA GRAS for food; allowed in cosmetics without specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonium Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Ammonium Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1288 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS DB |
| NOAEL | 1400 mg/kg bw/day | oral | rabbit | Chronic | COSMOS DB |
| NOAEL | 1490 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
| NOAEL | 1650 mg/kg bw/day | oral | sheep | Short Term Toxicity | COSMOS DB |
| NOAEL | 1792 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
| NOAEL | =256 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =284 mg/kg bw/day | oral | Rat | chronic | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ammonium Sulfate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Filler
Flame retardant
Flavouring and nutrient
Food preservative
Leavening agent
Processing aids not otherwise specified
Reducing agent
Soil amendments
Stabilizing agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Ammonium Sulfate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
endocrine_disruptor
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ammonium Sulfate by CAS number or substance name.
Studies
7
Lowest NOAEL
256 mg/kg bw/day
Highest NOAEL
1792 mg/kg bw/day
ECHA
COSMOS DB
Known Synonyms
Sulfuric acid diammonium salt
Actamaster
Caswell No. 048
EINECS 231-984-1
EPA Pesticide Chemical Code 005601
NSC 77671
Sulfatom ammoniya
UNII-SU46BAM238
(NH4)2SO4
ammonium sulfate (2:1)
mascagnite
Chemical Function
Viscosity modifier
Thickening agent
Reducing agent
Flavouring and nutrient
Soil amendments
Catalyst
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMMONIUM SULFATE
ChEMBL ID
CHEMBL2107724
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Ammonium sulfate
E Number
E517
Food Category
preservative
Frequently Asked Questions
Is Ammonium Sulfate allowed in the EU?
Ammonium Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Sulfate do in cosmetics?
Ammonium Sulfate functions as: Buffering, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 7783-20-2.
What is the NOAEL for Ammonium Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Sulfate is 1288 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS DB.
Is Ammonium Sulfate used outside cosmetics?
Ammonium Sulfate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ammonium Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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