Good Cosmetic Ingredient NOAEL Data

Ammonium Sulfate

INCI: AMMONIUM SULFATE

CAS Number
7783-20-2
Function
Buffering, viscosity controlling
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; FDA GRAS for food; allowed in cosmetics without specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for Ammonium Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1400 mg/kg bw/day oral rabbit Chronic COSMOS_DB
NOAEL 1650 mg/kg bw/day oral sheep Short Term Toxicity COSMOS_DB
NOAEL 1490 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1288 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 1792 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1400 mg/kg bw/day oral rabbit Chronic COSMOS_DB
dose_tested 1288 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 256 mg/kg bw/day oral rat oral REACH
NOAEL 886 mg/kg bw/day oral rat oral REACH

Expert Verdict

Potential skin and eye irritant at high concentrations; ammonia release at elevated pH; avoid in formulations above pH 8-9 to prevent free ammonia generation

⚠️
Concern Level: Low

Regulatory Flags

endocrine_disruptor fda_food_additive

Frequently Asked Questions

Is Ammonium Sulfate safe in cosmetics?

Potential skin and eye irritant at high concentrations; ammonia release at elevated pH; avoid in formulations above pH 8-9 to prevent free ammonia generation The EU classifies Ammonium Sulfate as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.

Is Ammonium Sulfate allowed in the EU?

Ammonium Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonium Sulfate do in cosmetics?

Ammonium Sulfate functions as: Buffering, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 7783-20-2.

What is the Margin of Safety for Ammonium Sulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ammonium Sulfate?

The NOAEL (No Observed Adverse Effect Level) for Ammonium Sulfate is 1400 mg/kg bw/day based on a Chronic study via oral route in rabbit. A total of 9 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Ammonium Sulfate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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