Good Cosmetic Ingredient SCCS/CIR Reviewed

Anhydrogalactose

INCI: ANHYDROGALACTOSE

CAS Number
28251-55-0
Function
Antioxidant, Humectant, Skin Conditioning Agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Final Report (September 2021): Safe in present practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 1000 mg/kg/d (oral)

Saccharide Hydrolysate, and Saccharide Isomerate are safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics, Anhydrogalactose, Anhydroglucitol, A

cir
Verdict: safe
NOAEL: 8.55 mg/kg/d (oral)

Saccharide Hydrolysate, and Saccharide Isomerate are safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics, Anhydrogalactose, Anhydroglucitol, A

Expert Verdict

Anti-melanogenic activity observed in vitro at high concentrations (50 µg/mL on B16F10 melanoma cells), but Panel considered this model of questionable predictive utility for in vivo skin lightening.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Anhydrogalactose safe in cosmetics?

Anti-melanogenic activity observed in vitro at high concentrations (50 µg/mL on B16F10 melanoma cells), but Panel considered this model of questionable predictive utility for in vivo skin lightening. The EU classifies Anhydrogalactose as "permitted". Safety rating: GOOD. This ingredient has been reviewed by cir.

Is Anhydrogalactose allowed in the EU?

Anhydrogalactose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Anhydrogalactose do in cosmetics?

Anhydrogalactose functions as: Antioxidant, Humectant, Skin Conditioning Agent. It is classified as a cosmetic ingredient in our database. CAS number: 28251-55-0.

What is the Margin of Safety for Anhydrogalactose?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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