Good Cosmetic Ingredient NOAEL Data GHS Classified

ANISOLE

CAS Number
100-66-3
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for ANISOLE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1230 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 1230 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

ANISOLE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is ANISOLE safe in cosmetics?

ANISOLE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies ANISOLE as "Permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is ANISOLE allowed in the EU?

ANISOLE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does ANISOLE do in cosmetics?

ANISOLE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 100-66-3.

What is the NOAEL for ANISOLE?

The NOAEL (No Observed Adverse Effect Level) for ANISOLE is 1230 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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