Ashwagandha (Withania Somnifera) Root Ext

Ashwagandha topical extracts are gaining traction as part of the holistic/adaptogen beauty movement with robust oral nutraceutical evidence, but topical adaptogenic claims lack sufficient peer-reviewed validation for cosmetic use. Antioxidant and soothing claims are substantiable from in-vitro withanolide data; stress-protection claims require stronger independent evidence. Globally unrestricted. The EU classifies Ashwagandha (Withania Somnifera) Root Ext as "permitted". Safety rating: GOOD.

Ashwagandha (Withania Somnifera) Root Ext EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

Ashwagandha (Withania Somnifera) Root Ext functions as: Extract from roots of Withania somnifera (ashwagandha). Active constituents: withanolides (steroidal lactones with anti-inflammatory, antioxidant, and adaptogenic properties), alkaloids, and saponins. Mechanisms in topical context: withanolide antioxidant and anti-inflammatory activity via NF-κB pathway inhibition; potential cortisol-modulation in stressed keratinocytes (adaptogenic claim). Strong oral evidence base for anti-stress and cortisol reduction; topical skincare evidence remains limited to in-vitro and supplier studies.. It is classified as a Active Ingredient in our database. CAS number: 90147-43-6.

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.