Good Active Ingredient

Pyridoxine

INCI: PYRIDOXINE

CAS Number
65-23-6
Function
Skin conditioning; vitamin B6 active form; enzyme co-factor support
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No standalone CIR cosmetic safety assessment identified. FDA-GRAS for food use. Systemic B6 supplementation linked with acne exacerbation in some reports — topical cosmetic relevance unconfirmed but relevant for acne-prone skin product development. Light/heat sensitivity: moderate; monitor photostability.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mild skin-conditioning B6 derivative with limited standalone cosmetic evidence. Shows most promise in multi-vitamin combination formulations for regeneration. Systemic acne-exacerbation link creates label sensitivity for acne-prone skin claims — topical evidence is not established. Safe at cosmetic use levels; best used as part of a vitamin complex rather than a primary single active.

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Concern Level: Low

Regulatory Flags

skin-conditioning combination-synergy acne-exacerbation-systemic-link moderate-photosensitivity no-cir-assessment safe-at-cosmetic-levels fda_food_additive

Frequently Asked Questions

Is Pyridoxine safe in cosmetics?

Mild skin-conditioning B6 derivative with limited standalone cosmetic evidence. Shows most promise in multi-vitamin combination formulations for regeneration. Systemic acne-exacerbation link creates label sensitivity for acne-prone skin claims — topical evidence is not established. Safe at cosmetic use levels; best used as part of a vitamin complex rather than a primary single active. The EU classifies Pyridoxine as "permitted". Safety rating: GOOD.

Is Pyridoxine allowed in the EU?

Pyridoxine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxine do in cosmetics?

Pyridoxine functions as: Skin conditioning; vitamin B6 active form; enzyme co-factor support. It is classified as a Active Ingredient in our database. CAS number: 65-23-6.

What is the Margin of Safety for Pyridoxine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Pyridoxine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

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Good
Calendula Extract (Calendula Officinalis Flower Extract)
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Spermidine
Good
Alpha-Glucan Oligosaccharide
Excellent
Retinoic Acid
Good
Browse all 30,000+ ingredients →
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