Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Niacinamide Cosmetic. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 600 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| dose_tested | 800 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 215 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Cosmetic-grade niacinamide offers evidence-backed multi-mechanism benefits with reduced flushing risk from lower niacin impurity levels; efficacy confirmed for barrier function, sebum reduction, and hyperpigmentation at concentrations ≥2%.
Regulatory Flags
Frequently Asked Questions
Is Niacinamide Cosmetic safe in cosmetics?
Cosmetic-grade niacinamide offers evidence-backed multi-mechanism benefits with reduced flushing risk from lower niacin impurity levels; efficacy confirmed for barrier function, sebum reduction, and hyperpigmentation at concentrations ≥2%. The EU classifies Niacinamide Cosmetic as "permitted". Safety rating: EXCELLENT. 9 toxicological study endpoint(s) are available in our database.
Is Niacinamide Cosmetic allowed in the EU?
Niacinamide Cosmetic EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Niacinamide Cosmetic do in cosmetics?
Niacinamide Cosmetic functions as: Water-soluble B3 vitamin, cosmetic-grade. Multi-mechanism active: barrier reinforcement via ceramide/fatty acid upregulation; sebum reduction; melanosome transfer inhibition for hyperpigmentation correction; anti-inflammatory via PGE2 suppression; anti-glycation. Effective 2–10%. Below ~2% functional benefits are unlikely.. It is classified as a Active Ingredient in our database. CAS number: 98-92-0.
What is the Margin of Safety for Niacinamide Cosmetic?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Niacinamide Cosmetic?
The NOAEL (No Observed Adverse Effect Level) for Niacinamide Cosmetic is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Is Niacinamide Cosmetic classified as hazardous under GHS?
Niacinamide Cosmetic carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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