NOAEL Studies Antioxidant

AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) NOAEL Studies

INCI: AVOBENZONE

CAS: 70356-09-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >16000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9510; row=16277; data_type=In Vivo; mixture=Chemical; chemical_name=1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione; preferred_name=1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione; dtxsid=DTXSID9044829; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9044829; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rabbit dermal acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d6fe4b096bca8775c39; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14835/7/6/4?documentUUID=19d51077-936d-4d34-a6d8-a1a5d4e1dc02; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826175_15826176_15826177:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cd9937dc89a609f15012dee0becd902
ToxValDB_ECHA_IUCLID LOAEL =1000 mg/kg bw/day Rat oral chronic; 94 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed5e4b0a7c65d1cb1f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14835/7/6/2?documentUUID=19d51077-936d-4d34-a6d8-a1a5d4e1dc02; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835860_15835861:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3c20d28f3f531c90ab14d2b0a1555fa
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1becb9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14835/7/9/3?documentUUID=19d51077-936d-4d34-a6d8-a1a5d4e1dc02; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821340:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7dee3c465c6234d0a8b2b5106e2faab
ToxValDB_ECHA_IUCLID NOAEL =360 mg/kg bw/day Rabbit dermal acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d6fe4b096bca8775c39; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14835/7/6/4?documentUUID=19d51077-936d-4d34-a6d8-a1a5d4e1dc02; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826175_15826176_15826177:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ce4ae0a077d562efed07135606cfbec
ToxValDB_ECHA_IUCLID NOAEL =450 mg/kg bw/day Rat oral chronic; 94 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaed5e4b0a7c65d1cb1f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14835/7/6/2?documentUUID=19d51077-936d-4d34-a6d8-a1a5d4e1dc02; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835860_15835861:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6854742ae4a7cd77773b7930bc745c3e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier G63QQF2NOX UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G63QQF2NOX"}
openFDA substances FDA UNII substance identifier G63QQF2NOX UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G63QQF2NOX"}
openFDA substances FDA UNII substance identifier G63QQF2NOX UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G63QQF2NOX"}
openFDA substances FDA UNII substance identifier G63QQF2NOX UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H22O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G63QQF2NOX"}