Also known as: 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, EINECS 274-581-6, Avobenzona, Avobenzonum (+2 more)
INCI: AVOBENZONE
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) (CAS 70356-09-1) is a cosmetic antioxidant functioning as Broad-spectrum UVA filter (340-400nm). NOAEL 33.3333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 70356-09-1 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE).
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =360 mg/kg bw/day | dermal | Rabbit | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =450 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) across SCCS product categories, with measured dermal absorption where available.
8 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >1000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LOAEL | >360 mg/kg-day | Rabbit | dermal | acute | ECHA IUCLID |
| LOAEL | =100 mg/kg-day | Rabbit | dermal | acute | ECHA IUCLID |
| LOAEL | =1000 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =360 mg/kg-day | Rabbit | dermal | acute | ECHA IUCLID |
| NOAEL | =450 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 38950 | 0 | - | - | non-sensitizer |
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Source list: II
no ER/AR binding detected
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| Cell proliferation | ER | EC50/IC50: N/A (no significant proliferation observed); LOEC: N/A; NOEC: >=3 uM mixed | inactive |
| ERb luciferase transcription | ERb | EC50/IC50: ~10-100 uM (EC50 not formally reported); LOEC: 10 uM; NOEC: 1 uM mixed | partial agonist (~60% E2 max) |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 5 | All cosmetics |
| IN | permitted_uv_filter | 5.0 | sunscreen and other cosmetic products |
| GCC | restricted | 5.0 | Sunscreen products |
| BR | permitted_uv_filter | 5 | Sunscreen products |
| ASEAN | permitted_uv_filter | 5% | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vitro | 0.59 | In vivo — clinical (plasma monitoring) | - | SCC/EC 2000; CIR review 2025 (2000) |
| measured_in_vitro | 11.5 | - | - | SCCS/1617/20 |
10 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE).
Public NOAEL study rows linked to AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) by CAS number or substance name.
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.59 | In vivo — clinical (plasma monitoring) | Commercial sunscreen |
| 11.5 | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 3 toxicological study endpoint(s) are available in our database.
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) functions as: Broad-spectrum UVA filter (340-400nm). It is classified as a Antioxidant in our database. CAS number: 70356-09-1.
The NOAEL (No Observed Adverse Effect Level) for AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) is =360 mg/kg bw/day based on a acute study via dermal route in Rabbit. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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