Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Benzophenone-12. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1500 ppm | oral | rat | oral | REACH |
| NOAEL | 3000 ppm | oral | dog | oral | REACH |
| NOAEL | >=6000 ppm | oral | dog | oral | REACH |
| NOAEL | 2000 ppm | oral | rat | oral | REACH |
| NOEL | 6000 ppm | oral | rat | oral | REACH |
| NOEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 12500 ppm | oral | rat | oral | REACH |
Expert Verdict
Prohibited in EU cosmetics; permitted in US as non-sunscreen ingredient with established safety profile but not currently used in cosmetic products per VCRP data
Regulatory Flags
Frequently Asked Questions
Is Benzophenone-12 safe in cosmetics?
Prohibited in EU cosmetics; permitted in US as non-sunscreen ingredient with established safety profile but not currently used in cosmetic products per VCRP data The EU classifies Benzophenone-12 as "prohibited". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is Benzophenone-12 allowed in the EU?
Benzophenone-12 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzophenone-12 do in cosmetics?
Benzophenone-12 functions as: UV absorber / light stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 1843-05-6.
What is the Margin of Safety for Benzophenone-12?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Benzophenone-12?
The NOAEL (No Observed Adverse Effect Level) for Benzophenone-12 is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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