NOAEL Studies Fragrance

Benzyl Benzoate NOAEL Studies

INCI: BENZYL BENZOATE

CAS: 120-51-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1617; row=13973; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl benzoate; preferred_name=Benzyl benzoate; dtxsid=DTXSID8029153; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1700 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1616; row=13974; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl benzoate; preferred_name=Benzyl benzoate; dtxsid=DTXSID8029153; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1619; row=13975; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl benzoate; preferred_name=Benzyl benzoate; dtxsid=DTXSID8029153; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2080 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_1621; row=13976; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl benzoate; preferred_name=Benzyl benzoate; dtxsid=DTXSID8029153; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5408; RecordID=ARPathway2016_670; DatasetName=ARPathway2016; DTXSID=DTXSID8029153; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Viability 93.27 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5348; Record_ID=skin_irritation_invitro_508; Data_Type=In Vitro; Formulation_Name=Benzyl benzoate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=EpiSkin Irritation; Endpoint=Viability; Response=93.27; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability 89.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5351; Record_ID=skin_irritation_invitro_512; Data_Type=In Vitro; Formulation_Name=Benzyl benzoate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=EpiDerm Irritation; Endpoint=Viability; Response=89.4; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability 110.03 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5352; Record_ID=skin_irritation_invitro_510; Data_Type=In Vitro; Formulation_Name=Benzyl benzoate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=EpiSkin Irritation; Endpoint=Viability; Response=110.03; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability 101.3 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5353; Record_ID=skin_irritation_invitro_513; Data_Type=In Vitro; Formulation_Name=Benzyl benzoate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=EpiDerm Irritation; Endpoint=Viability; Response=101.3; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability 109.8 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5355; Record_ID=skin_irritation_invitro_514; Data_Type=In Vitro; Formulation_Name=Benzyl benzoate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=EpiDerm Irritation; Endpoint=Viability; Response=109.8; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability (18 hours) 110.4 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=5347; Record_ID=skin_irritation_invitro_201; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=110.4; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_irritation Viability (42 hours) 74.5 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=5349; Record_ID=skin_irritation_invitro_201; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=74.5; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD86, EC150 >1485.736 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8222; Record_ID=skin_sensitization_invitro_2245; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=212.248; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1485.736; Converted_Response_Unit=ug/mL; Response=1485.736; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization CD86, EC150 >200 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8655; Record_ID=skin_sensitization_invitro_2395; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization CV75 297.2 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2307; Record_ID=skin_sensitization_invitro_565; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=h-CLAT; Endpoint=CV75; Reported_Response=297.2; Reported_Response_Unit=ug/mL; Response=297.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization CV75 297 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3792; Record_ID=skin_sensitization_invitro_863; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=h-CLAT; Endpoint=CV75; Reported_Response=297; Reported_Response_Unit=ug/mL; Response=297; Response_Unit=ug/mL; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi et al. 2013; 23824015; 10.2131/jts.38.599; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Depletion Cys 0.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=290; Record_ID=skin_sensitization_invitro_96; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.2; Reported_Response_Unit=%; Response=0.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Depletion Lys 3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=288; Record_ID=skin_sensitization_invitro_96; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3; Reported_Response_Unit=%; Response=3; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Depletion Lys + Cys 1.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=291; Record_ID=skin_sensitization_invitro_96; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization EC1.5 72.49 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4935; Record_ID=skin_sensitization_invitro_1142; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=72.489000000000004; Reported_Response_Unit=uM; Response=72.49; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization EC3 142.5 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4937; Record_ID=skin_sensitization_invitro_1142; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=142.46899999999999; Reported_Response_Unit=uM; Response=142.5; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization EC3 17 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=12995; Record_ID=skin_sensitization_invivo_2941; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=LLNA; Endpoint=EC3; Response=17; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization IC50 767.19 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4939; Record_ID=skin_sensitization_invitro_1142; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=767.19; Reported_Response_Unit=uM; Response=767.19; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Imax 5.75 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4941; Record_ID=skin_sensitization_invitro_1142; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=5.75; Reported_Response_Unit=Unitless; Response=5.75; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4215; Record_ID=skin_sensitization_invivo_1022; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90229-0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Induction dose per skin area 19440 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4213; Record_ID=skin_sensitization_invivo_1022; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=19440; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90229-0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4219; Record_ID=skin_sensitization_invivo_1022; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8029153; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90229-0|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029153
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =800 mg/kg bw/day Rat oral chronic; 7 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca35e4b0a7c65d220b95; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13634/7/6/2?documentUUID=f5a1fe36-6f3f-4e95-92d9-a61f8e73dc74; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15833600:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee94b3ffe51d87ad625311ce502dabc5
ToxValDB_ECHA_IUCLID NOAEL =781 mg/kg bw/day Rat dermal short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61db5e4b096bca8776c2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13634/7/6/4?documentUUID=f5a1fe36-6f3f-4e95-92d9-a61f8e73dc74; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15826267:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06ea1673e81693debc0f55d9ea62502a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =14.1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630060:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46b57168bb2d9eaad5196c6dc869abab
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier N863NB338G UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N863NB338G"}
openFDA substances FDA UNII substance identifier N863NB338G UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N863NB338G"}
openFDA substances FDA UNII substance identifier N863NB338G UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N863NB338G"}
openFDA substances FDA UNII substance identifier N863NB338G UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N863NB338G"}