Moderate Fragrance NOAEL Data GHS Classified Sensitization Data Dermal Penetration

Benzyl Benzoate

INCI: BENZYL BENZOATE

CAS Number
120-51-4
Function
fragrance; solvent; anti-parasitic
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off
🇺🇸 US Status permitted
US Notes Permitted; RIFM-assessed; also used as pharmaceutical anti-parasitic agent

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Benzyl Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 781 mg/kg bw/day dermal rat dermal REACH
NOAEL 2 other dermal code:3484 dermal REACH
NOAEL 400 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 400 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Sensitization Profile

Contact sensitization data for Benzyl Benzoate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.4%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Benzyl Benzoate, relevant to systemic exposure and MoS calculations.

Absorption %
18-32%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
212.2 Da
Log P
3.97
Systemic Absorption
yes
Topical Bioavailability
12-28%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

EU declarable fragrance allergen and key ylang ylang constituent with mandatory labelling requirements above specified thresholds; moderate sensitization profile with functions as fixative and solvent in fragrance compositions.

⚠️
Concern Level: Moderate

Regulatory Flags

allergen-eu sensitization-risk eu-labelling-required ifra-restricted original-26-allergen eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Benzyl Benzoate safe in cosmetics?

EU declarable fragrance allergen and key ylang ylang constituent with mandatory labelling requirements above specified thresholds; moderate sensitization profile with functions as fixative and solvent in fragrance compositions. The EU classifies Benzyl Benzoate as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is Benzyl Benzoate allowed in the EU?

Benzyl Benzoate EU regulatory status: restricted. Maximum allowed concentration: Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzyl Benzoate do in cosmetics?

Benzyl Benzoate functions as: fragrance; solvent; anti-parasitic. It is classified as a Fragrance in our database. CAS number: 120-51-4.

What is the Margin of Safety for Benzyl Benzoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Benzyl Benzoate?

The NOAEL (No Observed Adverse Effect Level) for Benzyl Benzoate is 781 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 6 study endpoints are available. Source: REACH.

Compliance Tools

Check Benzyl Benzoate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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