NOAEL Studies Fragrance

Benzyl Salicylate NOAEL Studies

INCI: BENZYL SALICYLATE

CAS: 118-58-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =5 mg/kg bw/day Rat oral: unspecified 91 days subchronic EFSA FEEDAP - 2012 - OutputID 607 - body weight - systemic - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785
EFSA NOAEL =5 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2785.; TITLE=Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2785; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614201:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_878fe799dcb39d5199e72b7d893f3c50
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =2227 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1516; row=2624; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl salicylate; preferred_name=Benzyl salicylate; dtxsid=DTXSID1024598; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024598; source_file=acute_oral.xlsx
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 841 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=570; Record_ID=adme_parameters_898; Data_Type=Measured; DTXSID=DTXSID1024598; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=841.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE adme parameters Fu 3.35e-8 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=569; Record_ID=adme_parameters_898; Data_Type=Measured; DTXSID=DTXSID1024598; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=3.35e-08; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 53.9165290737662 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5448; RecordID=ERPathway2016_375; DatasetName=ERPathway2016; DTXSID=DTXSID1024598; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=53.9165290737662; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine ACC 42.9334269653505 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5449; RecordID=ERPathway2016_375; DatasetName=ERPathway2016; DTXSID=DTXSID1024598; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=42.9334269653505; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine LOEL 3.7 mg/kg bw/day Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=767; Record_ID=endocrine_invivo_34; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=3.7; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Zhang et al. 2012; 22197706; 10.1016/j.toxlet.2011.12.004|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5444; RecordID=ARPathway2016_648; DatasetName=ARPathway2016; DTXSID=DTXSID1024598; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine Model Score 0.013 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5450; RecordID=ERPathway2016_375; DatasetName=ERPathway2016; DTXSID=DTXSID1024598; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.013; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE endocrine Uterine weight increase vs control 140 % Rat Oral Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=2236; Record_ID=endocrine_invivo_34; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=140; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Zhang et al. 2012; 22197706; 10.1016/j.toxlet.2011.12.004|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Positive reaction 0 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=402; Record_ID=skin_irritation_invivo_34; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability 87.8 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=979; Record_ID=skin_irritation_invitro_507; Data_Type=In Vitro; Formulation_Name=Benzyl salicylate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=EpiDerm Irritation; Endpoint=Viability; Response=87.8; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability 93.74 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=988; Record_ID=skin_irritation_invitro_503; Data_Type=In Vitro; Formulation_Name=Benzyl salicylate; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=EpiSkin Irritation; Endpoint=Viability; Response=93.74; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability 101 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=981; Record_ID=skin_irritation_invitro_509; Data_Type=In Vitro; Formulation_Name=Benzyl salicylate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=EpiDerm Irritation; Endpoint=Viability; Response=101; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability 103.2 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=978; Record_ID=skin_irritation_invitro_511; Data_Type=In Vitro; Formulation_Name=Benzyl salicylate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=EpiDerm Irritation; Endpoint=Viability; Response=103.2; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability 121.37 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=980; Record_ID=skin_irritation_invitro_504; Data_Type=In Vitro; Formulation_Name=Benzyl salicylate; Concentration=98; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=EpiSkin Irritation; Endpoint=Viability; Response=121.37; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability (18 hours) 115.7 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=987; Record_ID=skin_irritation_invitro_202; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=115.7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin irritation Viability (42 hours) 77 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=982; Record_ID=skin_irritation_invitro_202; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=77; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 66.17 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8659; Record_ID=skin_sensitization_invitro_2396; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=66.17; Reported_Response_Unit=ug/mL; Response=66.17; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization CV75 38 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1658; Record_ID=skin_sensitization_invitro_406; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=h-CLAT; Endpoint=CV75; Reported_Response=38; Reported_Response_Unit=ug/mL; Response=38; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 12.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4095; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=12.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4110; Record_ID=skin_sensitization_invivo_998; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=25; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Concentration, one positive response 10 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4091; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=10; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Concentration, one positive response 20 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4106; Record_ID=skin_sensitization_invivo_998; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=20; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Depletion Cys 3.8 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=103; Record_ID=skin_sensitization_invitro_28; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.8; Reported_Response_Unit=%; Response=3.8; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Depletion Lys 1.5 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=160; Record_ID=skin_sensitization_invitro_28; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.5; Reported_Response_Unit=%; Response=1.5; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization EC1.5 8.422 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4798; Record_ID=skin_sensitization_invitro_1108; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=8.4220000000000006; Reported_Response_Unit=uM; Response=8.422; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization EC3 2.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13002; Record_ID=skin_sensitization_invivo_2951; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=LLNA; Endpoint=EC3; Response=2.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization EC3 2.9 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12793; Record_ID=skin_sensitization_invivo_2802; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=LLNA; Endpoint=EC3; Response=2.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization EC3 40.88 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4800; Record_ID=skin_sensitization_invitro_1108; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=40.881999999999998; Reported_Response_Unit=uM; Response=40.88; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization IC50 110.98 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4802; Record_ID=skin_sensitization_invitro_1108; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=110.98; Reported_Response_Unit=uM; Response=110.98; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Imax 5.51 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4804; Record_ID=skin_sensitization_invitro_1108; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=5.51; Reported_Response_Unit=Unitless; Response=5.51; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4094; Record_ID=skin_sensitization_invivo_996; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Incidence of positive responses 4 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4103; Record_ID=skin_sensitization_invivo_998; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Incidence of positive responses 8 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4088; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area 6200 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4115; Record_ID=skin_sensitization_invivo_1000; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area 13500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4087; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=13500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area 17720 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4122; Record_ID=skin_sensitization_invivo_1001; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=17720; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area 19440 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4116; Record_ID=skin_sensitization_invivo_995; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=19440; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90236-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area 20250 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4092; Record_ID=skin_sensitization_invivo_996; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=20250; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 8438 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4097; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=8438; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 16880 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4112; Record_ID=skin_sensitization_invivo_998; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=16880; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Induction dose per skin area, one positive response 6750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4093; Record_ID=skin_sensitization_invivo_994; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4090; Record_ID=skin_sensitization_invivo_995; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90236-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
NTP ICE skin sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4113; Record_ID=skin_sensitization_invivo_999; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024598; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1968; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18035470; 10.1016/j.fct.2007.09.036|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024598; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024598
SCCS Opinion 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0 - rat oral - NOAEL study p.40
SCCS Opinion NOAEL =3.4 - - oral 28 days NOAEL study p.40
SCCS Opinion NOAEL =4 mg/kg/day - oral 28 days repeated dose toxicity p.40
SCCS Opinion NOAEL =14 - - oral 14 days NOAEL study p.40
SCCS Opinion NOAEL =21 - - oral - NOAEL study p.40
SCCS Opinion NOAEL =24 - - dermal - NOAEL study p.58
SCCS Opinion NOAEL =26 - rat oral - NOAEL study p.40
SCCS Opinion NOAEL =75 mg/kg/day - - - NOAEL study p.57
SCCS Opinion NOAEL =100 - - oral - dermal absorption p.58
SCCS Opinion NOAEL =123 - - - - NOAEL study p.58
SCCS Opinion NOAEL =158 mg/kg/day rat oral Developmental developmental toxicity p.44
SCCS Opinion NOAEL =166 mg/kg/day rat - Developmental developmental toxicity p.44
SCCS Opinion NOAEL =214 mg/kg/day rat oral - genotoxicity Ref: https://echa, p.45
SCCS Opinion NOAEL =400 mg/kg/day - oral 28 days repeated dose toxicity p.40
SCCS Opinion NOAEL =400 mg/kg/d - oral - NOAEL study p.40
SCCS Opinion NOAEL =451 - - oral - NOAEL study p.40
SCCS Opinion NOAEL =2500 ppm rat oral - reproductive toxicity p.43
SCCS Opinion NOAEL =3000 ppm rat oral 90 days NOAEL study Ref: https://echa, p.41
SCCS Opinion NOAEL =4000 ppm rat oral Developmental developmental toxicity p.44
SCCS Opinion NOAEL =6000 ppm - oral - NOAEL study p.40
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =7.8 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630076:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6135bad5014c064fdfe99abacc5c32ba
ToxValDB Uterotrophic Hershberger DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Uterotrophic Hershberger DB LEL =3.7 mg/kg bw/day Rat oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713484:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f164c1155dcb466e330daee70aef317a
ToxValDB Uterotrophic Hershberger DB LEL =11.1 mg/kg bw/day Mouse oral short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713520:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b9853db701a21a0897220280e44b5e6
Regulatory source 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0 - rat oral - - p.40
Regulatory source - 3.4 - - oral 28 days - p.40
Regulatory source - 4 mg/kg/day - oral - - p.40
Regulatory source - 14 - - oral 14 days - p.40
Regulatory source - 21 - - oral - - p.40
Regulatory source - 24 - - dermal - - p.58
Regulatory source - 26 - rat oral - - p.40
Regulatory source - 75 mg/kg/day - - - - p.57
Regulatory source - 123 - - - - - p.58
Regulatory source - 123 - - oral - - p.58
Regulatory source - 400 mg/kg/d - oral - - p.40
Regulatory source - 451 - - oral - - p.40
Regulatory source - 3000 ppm rat oral 90 days - p.41
Regulatory source - 6000 ppm - oral - - p.40
Regulatory source dermal absorption 100 - - oral - dermal absorption p.58
Regulatory source developmental toxicity 158 mg/kg/day rat oral Developmental developmental toxicity p.44
Regulatory source developmental toxicity 166 mg/kg/day rat - Developmental developmental toxicity p.44
Regulatory source developmental toxicity 4000 ppm rat oral Developmental developmental toxicity p.44
Regulatory source genotoxicity 214 mg/kg/day rat oral - genotoxicity p.45
Regulatory source repeated dose toxicity 3.4 - - oral Sub-chronic repeated dose toxicity p.40
Regulatory source repeated dose toxicity 4 mg/kg/day - oral 28 days repeated dose toxicity p.40
Regulatory source repeated dose toxicity 400 mg/kg/day - oral 28 days repeated dose toxicity p.40
Regulatory source reproductive toxicity 166 mg/kg/day rat oral 90 days reproductive toxicity p.61
Regulatory source reproductive toxicity 214 mg/kg/day rat oral developmental reproductive toxicity p.61
Regulatory source reproductive toxicity 2500 ppm rat oral - reproductive toxicity p.43
Regulatory source reproductive toxicity 3000 ppm rat oral 90 days reproductive toxicity p.61
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WAO5MNK9TU UNII - - - chemical -