Bis-Trimethylbenzoyl Phenylphosphine Oxide
INCI: BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Bis-Trimethylbenzoyl Phenylphosphine Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 600 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Moderate skin sensitizer with direct skin contact risk in uncured products. Use restricted to nail products only per SCCS. Incomplete cure may leave free photoinitiator on skin surface. Not evaluated for leave-on or rinse-off skin products.
Regulatory Flags
Frequently Asked Questions
Is Bis-Trimethylbenzoyl Phenylphosphine Oxide safe in cosmetics?
Moderate skin sensitizer with direct skin contact risk in uncured products. Use restricted to nail products only per SCCS. Incomplete cure may leave free photoinitiator on skin surface. Not evaluated for leave-on or rinse-off skin products. The EU classifies Bis-Trimethylbenzoyl Phenylphosphine Oxide as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Bis-Trimethylbenzoyl Phenylphosphine Oxide allowed in the EU?
Bis-Trimethylbenzoyl Phenylphosphine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bis-Trimethylbenzoyl Phenylphosphine Oxide do in cosmetics?
Bis-Trimethylbenzoyl Phenylphosphine Oxide functions as: Photoinitiator / Artificial nail builder. It is classified as a cosmetic ingredient in our database. CAS number: 162881-26-7.
What is the Margin of Safety for Bis-Trimethylbenzoyl Phenylphosphine Oxide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Bis-Trimethylbenzoyl Phenylphosphine Oxide?
The NOAEL (No Observed Adverse Effect Level) for Bis-Trimethylbenzoyl Phenylphosphine Oxide is 600 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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