Butyl Maleate

INCI: BUTYL MALEATE

CAS Number
925-21-3 (mono-n-butyl maleate)
Function
Plasticizer, film former, monomer in copolymer synthesis
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Insufficient data โ€” no published MoS calculation for cosmetic use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Michael acceptor structural alert โ€” the maleate group is electrophilic and can react with skin proteins, raising sensitization risk. If used only as a copolymer building block with negligible free monomer residual, risk is mitigated. Free monomer levels must be controlled and documented. Standalone use requires patch testing and LLNA data.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Butyl Maleate safe in cosmetics?

Michael acceptor structural alert โ€” the maleate group is electrophilic and can react with skin proteins, raising sensitization risk. If used only as a copolymer building block with negligible free monomer residual, risk is mitigated. Free monomer levels must be controlled and documented. Standalone use requires patch testing and LLNA data. The EU classifies Butyl Maleate as "permitted". Safety rating: MODERATE.

Is Butyl Maleate allowed in the EU?

Butyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyl Maleate do in cosmetics?

Butyl Maleate functions as: Plasticizer, film former, monomer in copolymer synthesis. It is classified as a cosmetic ingredient in our database. CAS number: 925-21-3 (mono-n-butyl maleate).

What is the Margin of Safety for Butyl Maleate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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