Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for C18-36 Acid Glycol Ester. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 1500 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Safe for use in cosmetics at current concentrations; naturally-derived fatty acid ester esterified with ethylene glycol; well-tolerated emollient and emulsifier with no restrictions in EU or US; low dermal penetration and no known sensitization.
Frequently Asked Questions
Is C18-36 Acid Glycol Ester safe in cosmetics?
Safe for use in cosmetics at current concentrations; naturally-derived fatty acid ester esterified with ethylene glycol; well-tolerated emollient and emulsifier with no restrictions in EU or US; low dermal penetration and no known sensitization. The EU classifies C18-36 Acid Glycol Ester as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is C18-36 Acid Glycol Ester allowed in the EU?
C18-36 Acid Glycol Ester EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does C18-36 Acid Glycol Ester do in cosmetics?
C18-36 Acid Glycol Ester functions as: Emollient, emulsifying agent, skin conditioning agent, surfactant; forms stable oil-in-water emulsions, increases viscosity, softens and smoothes skin. It is classified as a cosmetic ingredient in our database. CAS number: 94944-95-3.
What is the Margin of Safety for C18-36 Acid Glycol Ester?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for C18-36 Acid Glycol Ester?
The NOAEL (No Observed Adverse Effect Level) for C18-36 Acid Glycol Ester is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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