Is Cetylamine Hydrofluoride safe in cosmetics?
Cetylamine Hydrofluoride has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Cetylamine Hydrofluoride
Also known as: Cetylamine-HF, EINECS 221-588-7, Cetylaminhydrofluorid, Hetaflurum, UNII-S58EH61Q1Y
INCI: CETYLAMINE HYDROFLUORIDE
Cetylamine Hydrofluoride (CAS 3151-59-5) is a cosmetic cosmetic ingredient functioning as Oral care agent (anticaries/fluoride source). EU Regulation 1223/2009 status: restricted, max 0.15%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3151-59-5 →
Auto-generated CPSR Part A draft with source citations
Function
Oral care agent (anticaries/fluoride source)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
hexadecan-1-amine;hydrofluoride
InChIKey
KMXTYZBQPJXGNK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.15%
US US Status
permitted
US Notes
FDA regulated as OTC anticaries active ingredient under OTC Drug Monograph when used in oral care
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cetylamine Hydrofluoride.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Oral products. Max: 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 %
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Pharmaceutical
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Cetylamine Hydrofluoride.
Regulatory Flags
eu_cosing_listed
Known Synonyms
Cetylamine-HF
EINECS 221-588-7
Cetylaminhydrofluorid
Hetaflurum
UNII-S58EH61Q1Y
Chemical Function
Pharmaceutical
Regulatory Lists
Europe; Personal care; restricted
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HETAFLUR
ChEMBL ID
CHEMBL2104336
Max Phase
2
Frequently Asked Questions
Is Cetylamine Hydrofluoride allowed in the EU?
Cetylamine Hydrofluoride EU regulatory status: restricted. Maximum allowed concentration: 0.15%. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetylamine Hydrofluoride do in cosmetics?
Cetylamine Hydrofluoride functions as: Oral care agent (anticaries/fluoride source). It is classified as a cosmetic ingredient in our database. CAS number: 3151-59-5.
Is Cetylamine Hydrofluoride used outside cosmetics?
Cetylamine Hydrofluoride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cetylamine Hydrofluoride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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