Is Cetylhydroxyproline Palmitamide safe in cosmetics?
Cetylhydroxyproline Palmitamide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Cetylhydroxyproline Palmitamide
Also known as: UNII-74ONU0S62G, L-Proline, 4-hydroxy-1-(1-oxohexadecyl)-, hexadecyl ester, (4R)-, Pseudoceramide 391
INCI: CETYLHYDROXYPROLINE PALMITAMIDE
Cetylhydroxyproline Palmitamide (CAS 791838-11-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning, skin protecting (ceramide-like lipid based on amino acid. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 791838-11-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, skin protecting (ceramide-like lipid based on amino acid proline)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexadecyl (2S,4R)-1-hexadecanoyl-4-hydroxypyrrolidine-2-carboxylate
InChIKey
GOVINWHEYOSPAK-GPOMZPHUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permitted; used in marketed products (Physicians Formula, SkinBetter Science, etc.)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cetylhydroxyproline Palmitamide.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Cetylhydroxyproline Palmitamide.
Known Synonyms
UNII-74ONU0S62G
L-Proline, 4-hydroxy-1-(1-oxohexadecyl)-, hexadecyl ester, (4R)-
Pseudoceramide 391
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Cetylhydroxyproline Palmitamide allowed in the EU?
Cetylhydroxyproline Palmitamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetylhydroxyproline Palmitamide do in cosmetics?
Cetylhydroxyproline Palmitamide functions as: Skin conditioning, skin protecting (ceramide-like lipid based on amino acid proline). It is classified as a cosmetic ingredient in our database. CAS number: 791838-11-4.
Is Cetylhydroxyproline Palmitamide used outside cosmetics?
Cetylhydroxyproline Palmitamide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cetylhydroxyproline Palmitamide compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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