Is Chymotrypsin safe in cosmetics?
Chymotrypsin has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Chymotrypsin
INCI: CHYMOTRYPSIN
Chymotrypsin (CAS 9004-07-3) is a cosmetic cosmetic ingredient functioning as Enzyme. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 9004-07-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chymotrypsin is classified GHS Danger (H315, H319, H334, H335) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Enzyme
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted for use in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chymotrypsin.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantHealth Hazard
Hazard Class and Category
STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1
Hazard Statements
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, firming", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "E…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Chymotrypsin.
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
chymotrypsin
ChEMBL ID
CHEMBL1201465
Frequently Asked Questions
Is Chymotrypsin allowed in the EU?
Chymotrypsin EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Chymotrypsin do in cosmetics?
Chymotrypsin functions as: Enzyme. It is classified as a cosmetic ingredient in our database. CAS number: 9004-07-3.
Is Chymotrypsin used outside cosmetics?
Chymotrypsin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chymotrypsin have different safety status in cosmetics vs industrial chemicals?
Chymotrypsin is classified GHS Danger (H315, H319, H334, H335) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Chymotrypsin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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