Good Cosmetic Ingredient NOAEL Data

CI 15985

CAS Number
2783-94-0
Function
Colorant (yellow)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted – FD&C Yellow No. 6 (permanently listed, certification required)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for CI 15985. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral swine Subchronic COSMOS_DB
NOAEL 2400 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 750 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

EU requires food-grade purity (E110); rare intolerance in sensitive individuals.

⚠️
Concern Level: Low

Regulatory Flags

colorant eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is CI 15985 safe in cosmetics?

EU requires food-grade purity (E110); rare intolerance in sensitive individuals. The EU classifies CI 15985 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is CI 15985 allowed in the EU?

CI 15985 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 15985 do in cosmetics?

CI 15985 functions as: Colorant (yellow). It is classified as a cosmetic ingredient in our database. CAS number: 2783-94-0.

What is the Margin of Safety for CI 15985?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 15985?

The NOAEL (No Observed Adverse Effect Level) for CI 15985 is 1000 mg/kg bw/day based on a Subchronic study via oral route in swine. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check CI 15985 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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