Good Cosmetic Ingredient NOAEL Data

Acid Red 92

INCI: CI 45410

CAS Number
18472-87-2
Function
Colorant (halogenated xanthene dye; Phloxin B)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 1%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes D&C Red No. 28 โ€” permanently listed, batch certification required; drugs and cosmetics generally

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Acid Red 92. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Photosensitizer potential (halogenated fluorescein derivative); strict purity criteria on EU-side; not for eye area, injections, or surgical sutures in the US

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Concern Level: Moderate

Regulatory Flags

potential-allergen colorant eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is Acid Red 92 safe in cosmetics?

Photosensitizer potential (halogenated fluorescein derivative); strict purity criteria on EU-side; not for eye area, injections, or surgical sutures in the US The EU classifies Acid Red 92 as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Acid Red 92 allowed in the EU?

Acid Red 92 EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Red 92 do in cosmetics?

Acid Red 92 functions as: Colorant (halogenated xanthene dye; Phloxin B). It is classified as a cosmetic ingredient in our database. CAS number: 18472-87-2.

What is the Margin of Safety for Acid Red 92?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Red 92?

The NOAEL (No Observed Adverse Effect Level) for Acid Red 92 is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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