NOAEL Studies Colorant

CI 15985 Yellow 6 Lake NOAEL Studies

INCI: CI 15985 YELLOW 6 LAKE

CAS: 2783-94-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day swine oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2400 mg/kg bw/day mouse oral 560 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 750 mg/kg bw/day rat oral 901 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 834 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7500 mg/kg bw/day mouse oral 686 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3750 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 243 mg/kg bw/day mouse oral 115 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Dog oral: unspecified 2555 days chronic/long term toxicity EFSA ANS - 2009 - OutputID 394 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive - doi:10.2903/j.efsa.2009.1330
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =375 mg/kg bw/day Rat oral: feed 28 days reproduction toxicity EFSA ANS - 2014 - OutputID 2521 - body weight - developmental - Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E110) - doi:10.2903/j.efsa.2014.3765
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =1 mg/kg bw/day Consumers - - ADI EFSA ANS - 2009 - OutputID 394 - Consumers - Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive - doi:10.2903/j.efsa.2009.1330
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =4 mg/kg bw/day Consumers - - ADI EFSA ANS - 2014 - OutputID 2521 - Consumers - Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E110) - doi:10.2903/j.efsa.2014.3765
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =1 mg/kg bw/day Consumers - - ADI EFSA ANS - 2009 - OutputID 394 - Consumers - Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive - doi:10.2903/j.efsa.2009.1330
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =4 mg/kg bw/day Consumers - - ADI EFSA ANS - 2014 - OutputID 2521 - Consumers - Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E110) - doi:10.2903/j.efsa.2014.3765
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (provisional) =1 mg/kg bw/day Consumers - - ADI (provisional) EFSA ANS - 2011 - OutputID 487 - Consumers - Revised exposure assessment for Sunset Yellow FCF based on the proposed revised maximum permitted levels of use as a food additive - doi:10.2903/j.efsa.2011.2349
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (provisional) =1 mg/kg bw/day Consumers - - ADI (provisional) EFSA ANS - 2011 - OutputID 487 - Consumers - Revised exposure assessment for Sunset Yellow FCF based on the proposed revised maximum permitted levels of use as a food additive - doi:10.2903/j.efsa.2011.2349
IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"8, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"8, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"8, Sup 7"}
INCHEM_WHO_jecfa_jecmono_v65je01 137 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.60.6 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=e589b6c22e2de563; raw_unit=mg/kg body weight; context=At its twenty-sixth meeting, the Committee established a temporary ADI of 0-0.6 mg/kg body weight (bw) for sodium aluminium phosphate (Annex 1, reference 59).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-55 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b0fe12504c6eaf71; raw_unit=mg/kg body weight; context=he group of benzyl derivatives, including benzoic acid and benzyl benzoate, would not present any safety concerns when used at the estimated current levels and confirmed the group ADI of 0-5 mg/kg body weight (bw) as benzoic acid equivalents (Annex 1, reference 122).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-1010 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=25efe5ad4ad6afdd; raw_unit=mg/kg bw; context=889) was evaluated at the eleventh meeting of the Committee and assigned an ADI of 0-10 mg/kg bw (Annex 1, reference 14).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI =50 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=aaf4cf5d7481d8d2; raw_unit=mg/kg; context=Assuming that solid food (3 kg) and beverages (6 litres) are each allocated half of the upper limit of the ADI, a maximum concentration for Benzoe Tonkinensis of 50 mg/kg in food and 25 mg/kg in beverages can be calculated.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.750.75 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b680f384cf422dd1; raw_unit=mg/kg body weight; context=At its thirteenth meeting, the Committee reviewed these data and established a temporary ADI of 0-0.75 mg/kg body weight (bw) based on a no-observed-effect level (NOEL)1 of 150 mg/kg bw per day in a long-term feeding study in rats.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.1250.125 mg/kg bw/day Mouse oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f38f029feffb3cb0; raw_unit=mg/kg bw; context=At its eighteenth meeting, the Committee considered an additional long-term feeding study in mice that had become available and revised the temporary ADI to 0-0.125 mg/kg bw based on a NOEL of 25 mg/kg bw per day (this NOEL assumed 500 mg/kg in the diet to be equivalent to 25 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-44 mg/kg bw/day Rat; Mouse - long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=539c59207c6f610a; raw_unit=mg/kg bw.; context=The results of this study in rats and a reconsideration of the severity of the renal effects observed in the long-term study in mice led the Committee to establish an ADI of 0-4 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-11 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=360556bcdf13005c; raw_unit=mg/kg body weight; context=At its thirteenth meeting, the Committee reviewed the available data and established a temporary ADI of 0-1 mg/kg body weight (bw) based on a no-observed-effect level (NOEL)1 of 500 mg/kg bw per day in a long-term feeding study in rats.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.50.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=62ba07ed2d65dbff; raw_unit=mg/ kg bw; context=Using the results of that study, the Committee established a temporary ADI of 0-0.5 mg/ kg bw based on the absence of any adverse effects at the highest tested dose of 50 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=39652b2c5cdab945; raw_unit=mg/kg bw.; context=At the twenty-sixth meeting, the Committee considered new studies on long- term and reproductive toxicity and established an ADI of 0-2.5 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.80.8 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8c66697c7f6b105d; raw_unit=mg/kg body weight; context=Polydimethyl siloxane M The Committee withdrew the temporary ADI of 0-0.8 mg/kg body weight and re-established the ADI of 0-1.5 mg/kg body weight, originally established at the eighteenth meeting.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.80.8 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8c66697c7f6b105d; raw_unit=mg/kg body weight; context=Polydimethyl siloxane M The Committee withdrew the temporary ADI of 0-0.8 mg/kg body weight and re-established the ADI of 0-1.5 mg/kg body weight, originally established at the eighteenth meeting.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.60.6 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=e589b6c22e2de563; raw_unit=mg/kg body weight; context=At its twenty-sixth meeting, the Committee established a temporary ADI of 0-0.6 mg/kg body weight (bw) for sodium aluminium phosphate (Annex 1, reference 59).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-55 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b0fe12504c6eaf71; raw_unit=mg/kg body weight; context=he group of benzyl derivatives, including benzoic acid and benzyl benzoate, would not present any safety concerns when used at the estimated current levels and confirmed the group ADI of 0-5 mg/kg body weight (bw) as benzoic acid equivalents (Annex 1, reference 122).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-1010 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=25efe5ad4ad6afdd; raw_unit=mg/kg bw; context=889) was evaluated at the eleventh meeting of the Committee and assigned an ADI of 0-10 mg/kg bw (Annex 1, reference 14).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI =50 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=aaf4cf5d7481d8d2; raw_unit=mg/kg; context=Assuming that solid food (3 kg) and beverages (6 litres) are each allocated half of the upper limit of the ADI, a maximum concentration for Benzoe Tonkinensis of 50 mg/kg in food and 25 mg/kg in beverages can be calculated.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.750.75 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b680f384cf422dd1; raw_unit=mg/kg body weight; context=At its thirteenth meeting, the Committee reviewed these data and established a temporary ADI of 0-0.75 mg/kg body weight (bw) based on a no-observed-effect level (NOEL)1 of 150 mg/kg bw per day in a long-term feeding study in rats.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.1250.125 mg/kg bw/day Mouse oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f38f029feffb3cb0; raw_unit=mg/kg bw; context=At its eighteenth meeting, the Committee considered an additional long-term feeding study in mice that had become available and revised the temporary ADI to 0-0.125 mg/kg bw based on a NOEL of 25 mg/kg bw per day (this NOEL assumed 500 mg/kg in the diet to be equivalent to 25 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-44 mg/kg bw/day Rat; Mouse - long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=539c59207c6f610a; raw_unit=mg/kg bw.; context=The results of this study in rats and a reconsideration of the severity of the renal effects observed in the long-term study in mice led the Committee to establish an ADI of 0-4 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-11 mg/kg bw/day Rat oral long-term Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=360556bcdf13005c; raw_unit=mg/kg body weight; context=At its thirteenth meeting, the Committee reviewed the available data and established a temporary ADI of 0-1 mg/kg body weight (bw) based on a no-observed-effect level (NOEL)1 of 500 mg/kg bw per day in a long-term feeding study in rats.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.50.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=62ba07ed2d65dbff; raw_unit=mg/ kg bw; context=Using the results of that study, the Committee established a temporary ADI of 0-0.5 mg/ kg bw based on the absence of any adverse effects at the highest tested dose of 50 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=39652b2c5cdab945; raw_unit=mg/kg bw.; context=At the twenty-sixth meeting, the Committee considered new studies on long- term and reproductive toxicity and established an ADI of 0-2.5 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 ADI range:0-0.80.8 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8c66697c7f6b105d; raw_unit=mg/kg body weight; context=Polydimethyl siloxane M The Committee withdrew the temporary ADI of 0-0.8 mg/kg body weight and re-established the ADI of 0-1.5 mg/kg body weight, originally established at the eighteenth meeting.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL ~31 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9926972eba03a85d; raw_unit=mg/kg bw per day; context=The lowest-observed- adverse-effect level (LOAEL) from this study would be equivalent to a total of approximately 31 mg/kg bw per day, expressed as aluminium.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL ~35 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7c4e4b2392fbb24b; raw_unit=mg/kg bw per day; context=The LOAEL from this study would be equivalent to a total aluminium dose of approximately 35 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b12070cf8a338856; raw_unit=mg/kg bw per day; context=Overall, the authors concluded that the study indicated a LOAEL of 100 mg/kg bw per day and a NOAEL of 30 mg/kg bw per day (Semple, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL range:50-7575 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=223fb429a29d81e0; raw_unit=mg/kg bw per day; context=At its current meeting, the Committee noted that the new data did not substantially change the LOAEL range of 50-75 mg/kg bw per day, but one of the studies also provided a NOAEL of 30 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =20 mg/kg bw/day Hamster - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=392bcd517f838f17; raw_unit=mg/kg bw per day; context=A LOAEL of 20 mg/kg bw per day for cyanide was identified based on altered cerebellar development (Malomo et al., 2004). (b) Hamsters The Committee (Annex 1, reference 102) previously reviewed a study in which pregnant Golden hamsters were exposed to sodium cyanide on days 6-9 of gestation
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =2.4 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9c37579674a7cb39; raw_unit=mg/kg bw per day; context=A LOAEL of 2.4 mg/kg bw per day based on increased thyroid weight was determined for this study (Manzano et al., 2007).
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =1.35 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=226ff06d94a06abd; raw_unit=mg/kg bw per day; context=me-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =1.35 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=226ff06d94a06abd; raw_unit=mg/kg bw per day; context=me-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL ~31 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9926972eba03a85d; raw_unit=mg/kg bw per day; context=The lowest-observed- adverse-effect level (LOAEL) from this study would be equivalent to a total of approximately 31 mg/kg bw per day, expressed as aluminium.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL ~35 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7c4e4b2392fbb24b; raw_unit=mg/kg bw per day; context=The LOAEL from this study would be equivalent to a total aluminium dose of approximately 35 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b12070cf8a338856; raw_unit=mg/kg bw per day; context=Overall, the authors concluded that the study indicated a LOAEL of 100 mg/kg bw per day and a NOAEL of 30 mg/kg bw per day (Semple, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL range:50-7575 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=223fb429a29d81e0; raw_unit=mg/kg bw per day; context=At its current meeting, the Committee noted that the new data did not substantially change the LOAEL range of 50-75 mg/kg bw per day, but one of the studies also provided a NOAEL of 30 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =20 mg/kg bw/day Hamster - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=392bcd517f838f17; raw_unit=mg/kg bw per day; context=A LOAEL of 20 mg/kg bw per day for cyanide was identified based on altered cerebellar development (Malomo et al., 2004). (b) Hamsters The Committee (Annex 1, reference 102) previously reviewed a study in which pregnant Golden hamsters were exposed to sodium cyanide on days 6-9 of gestation
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =2.4 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9c37579674a7cb39; raw_unit=mg/kg bw per day; context=A LOAEL of 2.4 mg/kg bw per day based on increased thyroid weight was determined for this study (Manzano et al., 2007).
INCHEM_WHO_jecfa_jecmono_v65je01 LOAEL =1.35 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=226ff06d94a06abd; raw_unit=mg/kg bw per day; context=me-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL ~300 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=bd22bd36077e00c0; raw_unit=mg/kg bw per day; context=hat there were no differences between the control and test groups and that the dietary concentration of Iriodin® Ti 100K of 20 000 mg/kg was the no- observed-adverse-effect level (NOAEL) (equivalent to about 300 mg/kg bw per day, expressed as aluminium) (Jochmann, 1972;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =600 mg/L - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=2def14dd3c9159ca; raw_unit=mg/l; context=etardation of sexual development in the F1 females, attributed to inhibition of growth, and decreased body weight gain and liver and spleen weights in the F1 and F2 offspring, the NOAEL was 600 mg/l aluminium sulfate in the drinking- water, corresponding to 41.0 mg/kg bw per day (Fujii, 2009;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =6.47 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b5949277170cc618; raw_unit=mg/kg bw per day; context=Expressed as aluminium, the reported NOAEL from this study equates to 6.47 mg/kg bw per day from the test substance plus at least 1.6 mg/kg bw per day from the diet-i.e. a total of about 8 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =500 mg/L - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=46b185677eeb8235; raw_unit=mg/l; context=on of sexual development in the F1 females, attributed to inhibition of growth, and decreased body weight gain and liver, spleen and thymus weights in the F1 and F2 offspring, the NOAEL was 500 mg/l aluminium ammonium sulfate in the drinking- water, corresponding to 33.5 mg/kg bw per day (Fujii, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =3.81 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=913e2e929b069ef0; raw_unit=mg/kg bw per day; context=Expressed as aluminium, the reported NOAEL from this study equates to 3.81 mg/kg bw per day from the test substance plus at least 1.6 mg/kg bw per day Aluminium-containing food additives (addendum) 23 from the diet-that is, a total of about 6 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =200 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6be9591c1ac4bd92; raw_unit=mg/kg bw per day; context=The author considered that 1000 mg/kg bw per day was the NOAEL for systemic effects and 200 mg/kg bw per day was the NOAEL for local irritation (Beekhuijzen, 2007).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =30 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=deaabfe21d043e0b; raw_unit=mg/kg bw per day; context=Overall, the authors concluded that the study indicated a LOAEL of 100 mg/kg bw per day and a NOAEL of 30 mg/kg bw per day (Semple, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =500 mg/kg bw/day Rat oral 90-day Subchronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=27e939e3ec66e67f; raw_unit=mg/kg bw per day; context=Comparing the conservative dietary exposure estimate for Benzoe Tonkinensis of 0.2 mg/kg bw per day with the NOAEL of 500 mg/kg bw per day identified in a 90-day oral toxicity study in rats, the margin of exposure is at least 2500.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=90a9d8a8450bdf4d; raw_unit=mg/kg bw per day; context=Overall, it can be concluded that the NOAEL was 2500 mg/kg bw per day (i.e.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =246 mg/kg bw/day - - 13-week Subchronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0ff43bb245ee3789; raw_unit=mg/kg bw per day; context=Therefore, the NOAEL was identified as 246 mg/kg bw per day as TOS, the highest dose tested in the 13-week study.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =50 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c611713045f4189e; raw_unit=mg/kg bw per day; context=The NOAEL for this study is considered to be 50 mg/kg bw per day, based on the available summarized information reported in SCCNFP (2004). (b) Developmental toxicity No information on the developmental toxicity of Quinoline Yellow was available.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =3750 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=712fc0fa18afa4ac; raw_unit=mg/kg bw per day; context=males at the highest tested dose compared with control animals, it was less than 10%, a value not considered to be biologically significant; the no-observed- adverse-effect level (NOAEL) for this study is therefore considered to be 25 000 mg/kg diet (equivalent to 3750 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2250 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d5614ea2581c08de; raw_unit=mg/kg bw per day; context=However, based on deaths and a body weight decrement relative to the controls at 50 000 mg/kg diet, the NOAEL for the study is 15 000 mg/kg diet (equivalent to 2250 mg/kg bw per day) (USFDA, 1986). (b) Rat Sunset Yellow FCF (FD&C Yellow No.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =1250 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0b0ba72d1c3dea85; raw_unit=mg/kg bw per day; context=As the body weight decrement among males at the highest dose was less than 10%, a value not considered to be biologically significant, the NOAEL for this study is considered to be 25 000 mg/kg diet (equivalent to 1250 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =1500 mg/kg bw/day - oral chronic Chronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0376572d806e6510; raw_unit=mg/kg bw per day; context=Hence, the NOAEL for the chronic phase of the study is 30 000 mg/kg diet (equivalent to 1500 mg/kg bw per day) (USFDA, 1986).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =375 mg/kg bw/day - oral - Reproductive toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9f5da0aa9580e98c; raw_unit=mg/kg bw per day; context=Hence, the NOAEL for reproductive toxicity is 7500 mg/kg diet (equivalent to 375 mg/kg bw per day) (USFDA, 1986).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =6000 mg/kg bw/day - oral - Developmental toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=4405d7cfb1691081; raw_unit=mg/kg; context=Hence, in the absence of any effects on the reproductive parameters and inconsistent neurological outcomes, it can be concluded that the NOAEL for this study is 6000 mg/kg in the diet (approximately 1000 mg/kg bw per day), the highest dose tested (Tanaka, 1996). (b) Developmental toxicity No information on the developmental toxicity of Sunset Yellow FCF was available.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =4.5 mg/kg bw/day Rat - 13-week Reproductive toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=de1f19ebcd59a617; raw_unit=mg/kg bw; context=The Committee of Experts on Flavouring Substances of the Council of Europe (CoE, 2005) established a temporary maximum daily intake of 0.023 mg/ kg bw based on a NOAEL of 4.5 mg/kg bw from a 13-week study showing adverse reproductive effects on male rats, applying a safety factor of 200.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a26fd9d6716f88e4; raw_unit=mg/kg bw per day; context=A NOAEL of 2.7 mg/kg bw per day was determined based on a statistically significant decrease in relative cauda epididymis weight at the next higher dose level (NTP, 1993;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6ff0fa3a66a1bb5f; raw_unit=mg/kg bw per day; context=Based on reported behavioural changes and decreased thyroid hormones, the LOAEL and NOAEL 240 Cyanogenic glycosides (addendum) values identified for this study are 1.2 and 0.7 mg/kg bw per day, as cyanide, respectively (Jackson, 1988).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=15bf57925953355f; raw_unit=mg/kg bw per day; context=le daily intake (PMTDI) for fumonisins B1 (FB1), B2 (FB2) and B3 (FB3), alone or in combination, of 2 ug/kg body weight (bw) on the basis of the no- observed-adverse-effect level (NOAEL) of 0.2 mg/kg bw per day for kidney toxicity and application of an uncertainty factor of 100.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.005 mg/kg bw Rat - - Acute toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=e11f5a628c3ab783; raw_unit=ug/kg bw.; unit_normalization=converted from micrograms; context=Thus, the single-dose NOAEL for apoptosis in male Wistar rat liver would be below 5 ug/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =45 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f4cd1603e3e9f526; raw_unit=mg/kg bw per day; context=As only one dose was tested, a NOAEL could not be determined by the Committee, but would be below 45 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=91b2adfc47cad8b8; raw_unit=mg/kg bw per day; context=The NOAEL was 2.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=1 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f13bf9a5eeb2d922; raw_unit=mg/kg bw per day; context=In a previous study using a similar experimental design, the NOAEL for liver toxicity was greater than 1 mg/kg bw per day (Annex 1, reference 153, Table 5).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =4.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a5fbaa03d7f24578; raw_unit=mg/kg bw per day; context=The Committee concluded that, based on reduced body weight gain at and above 11.4 mg/kg bw per day, the NOAEL was 4.2 mg/kg bw per day, whereas for induction of GSTP+ foci, it was 11.4 mg/kg bw per day, and for lipid peroxidation, it was 21 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =15 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=934cb72de292e8cf; raw_unit=mg/kg bw per day; context=A NOAEL could Fumonisins (addendum) 347 not be determined by the Committee, as all treatment groups showed either liver pathology or reduced weight gains, but would be lower than 15 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.11 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a8ae0ed8293f3da3; raw_unit=mg/kg bw per day; context=er and kidney and the lack of any apparent time-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.03 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6359a7700c7e4b56; raw_unit=mg/kg bw per day; context=hology scores and the close correlation between fumonisin exposure, the pathology scores and the levels of total sphingoid bases and sphingoid base 1-phosphates in rat kidney, the NOAEL in this study could be 0.03 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.02 mg/kg bw/day Rabbit oral 24 weeks Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8d45c093febf19e8; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL was the dose of the control group, 0.02 mg/kg bw per day. (iii) Rabbits Crossbred male rabbits (22-24 weeks old, 1.36 ± 0.01 kg, 10 animals per group) were fed diets prepared with maize that had been inoculated with F. verticillioides MRC 826 at silking in the field.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.04 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c92617afbeccdb5b; raw_unit=mg/ kg bw per day; context=The authors Fumonisins (addendum) 363 concluded that the data indicated a NOAEL of 1 mg/kg diet, equivalent to 0.04 mg/ kg bw per day (Zomborszky-Kovács et al., 2002a,b).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.4 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c01018654903ff7d; raw_unit=mg/kg bw per day; context=The NOAEL was 10 mg FB1 and FB2 per kilogram diet, equivalent to 0.4 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.01 mg/kg bw/day - oral 28 days Neurotoxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=4beabb7c2ed8c10b; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL (intravenous) after 28 days for clinically defined neurological signs was 0.01 mg/kg bw per day. (vi) Other species Mule ducks (7 days old) were gavaged for 77 days with F. verticillioides (NRRL 34281) culture extract that was partially purified and contained FB1 at doses of 0, 2, 8, 32 and 128 mg/kg feed.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =8 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7a7a6ce3f47cfe3f; raw_unit=mg/kg diet; context=The NOAEL was 8 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d6be8b1934342874; raw_unit=mg/kg diet; context=The NOAEL was greater than 20 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg bw/day Mouse intraperitoneal 2 days Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7e5b290b3ff6e32e; raw_unit=mg/kg bw per day; context=The NOAEL for HFB1-induced NTDs and liver toxicity in mice is greater than 20 mg/kg bw per day when dosed for 2 days intraperitoneally.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=91b2adfc47cad8b8; raw_unit=mg/kg bw per day; context=The NOAEL was 2.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=1 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f13bf9a5eeb2d922; raw_unit=mg/kg bw per day; context=In a previous study using a similar experimental design, the NOAEL for liver toxicity was greater than 1 mg/kg bw per day (Annex 1, reference 153, Table 5).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =4.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a5fbaa03d7f24578; raw_unit=mg/kg bw per day; context=The Committee concluded that, based on reduced body weight gain at and above 11.4 mg/kg bw per day, the NOAEL was 4.2 mg/kg bw per day, whereas for induction of GSTP+ foci, it was 11.4 mg/kg bw per day, and for lipid peroxidation, it was 21 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =15 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=934cb72de292e8cf; raw_unit=mg/kg bw per day; context=A NOAEL could Fumonisins (addendum) 347 not be determined by the Committee, as all treatment groups showed either liver pathology or reduced weight gains, but would be lower than 15 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.11 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a8ae0ed8293f3da3; raw_unit=mg/kg bw per day; context=er and kidney and the lack of any apparent time-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.03 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6359a7700c7e4b56; raw_unit=mg/kg bw per day; context=hology scores and the close correlation between fumonisin exposure, the pathology scores and the levels of total sphingoid bases and sphingoid base 1-phosphates in rat kidney, the NOAEL in this study could be 0.03 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.02 mg/kg bw/day Rabbit oral 24 weeks Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8d45c093febf19e8; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL was the dose of the control group, 0.02 mg/kg bw per day. (iii) Rabbits Crossbred male rabbits (22-24 weeks old, 1.36 ± 0.01 kg, 10 animals per group) were fed diets prepared with maize that had been inoculated with F. verticillioides MRC 826 at silking in the field.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.04 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c92617afbeccdb5b; raw_unit=mg/ kg bw per day; context=The authors Fumonisins (addendum) 363 concluded that the data indicated a NOAEL of 1 mg/kg diet, equivalent to 0.04 mg/ kg bw per day (Zomborszky-Kovács et al., 2002a,b).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.4 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c01018654903ff7d; raw_unit=mg/kg bw per day; context=The NOAEL was 10 mg FB1 and FB2 per kilogram diet, equivalent to 0.4 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.01 mg/kg bw/day - oral 28 days Neurotoxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=4beabb7c2ed8c10b; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL (intravenous) after 28 days for clinically defined neurological signs was 0.01 mg/kg bw per day. (vi) Other species Mule ducks (7 days old) were gavaged for 77 days with F. verticillioides (NRRL 34281) culture extract that was partially purified and contained FB1 at doses of 0, 2, 8, 32 and 128 mg/kg feed.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =8 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7a7a6ce3f47cfe3f; raw_unit=mg/kg diet; context=The NOAEL was 8 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d6be8b1934342874; raw_unit=mg/kg diet; context=The NOAEL was greater than 20 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg bw/day Mouse intraperitoneal 2 days Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7e5b290b3ff6e32e; raw_unit=mg/kg bw per day; context=The NOAEL for HFB1-induced NTDs and liver toxicity in mice is greater than 20 mg/kg bw per day when dosed for 2 days intraperitoneally.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL ~300 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=bd22bd36077e00c0; raw_unit=mg/kg bw per day; context=hat there were no differences between the control and test groups and that the dietary concentration of Iriodin® Ti 100K of 20 000 mg/kg was the no- observed-adverse-effect level (NOAEL) (equivalent to about 300 mg/kg bw per day, expressed as aluminium) (Jochmann, 1972;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =600 mg/L - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=2def14dd3c9159ca; raw_unit=mg/l; context=etardation of sexual development in the F1 females, attributed to inhibition of growth, and decreased body weight gain and liver and spleen weights in the F1 and F2 offspring, the NOAEL was 600 mg/l aluminium sulfate in the drinking- water, corresponding to 41.0 mg/kg bw per day (Fujii, 2009;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =6.47 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=b5949277170cc618; raw_unit=mg/kg bw per day; context=Expressed as aluminium, the reported NOAEL from this study equates to 6.47 mg/kg bw per day from the test substance plus at least 1.6 mg/kg bw per day from the diet-i.e. a total of about 8 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =500 mg/L - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=46b185677eeb8235; raw_unit=mg/l; context=on of sexual development in the F1 females, attributed to inhibition of growth, and decreased body weight gain and liver, spleen and thymus weights in the F1 and F2 offspring, the NOAEL was 500 mg/l aluminium ammonium sulfate in the drinking- water, corresponding to 33.5 mg/kg bw per day (Fujii, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =3.81 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=913e2e929b069ef0; raw_unit=mg/kg bw per day; context=Expressed as aluminium, the reported NOAEL from this study equates to 3.81 mg/kg bw per day from the test substance plus at least 1.6 mg/kg bw per day Aluminium-containing food additives (addendum) 23 from the diet-that is, a total of about 6 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =200 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6be9591c1ac4bd92; raw_unit=mg/kg bw per day; context=The author considered that 1000 mg/kg bw per day was the NOAEL for systemic effects and 200 mg/kg bw per day was the NOAEL for local irritation (Beekhuijzen, 2007).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =30 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=deaabfe21d043e0b; raw_unit=mg/kg bw per day; context=Overall, the authors concluded that the study indicated a LOAEL of 100 mg/kg bw per day and a NOAEL of 30 mg/kg bw per day (Semple, 2010;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =500 mg/kg bw/day Rat oral 90-day Subchronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=27e939e3ec66e67f; raw_unit=mg/kg bw per day; context=Comparing the conservative dietary exposure estimate for Benzoe Tonkinensis of 0.2 mg/kg bw per day with the NOAEL of 500 mg/kg bw per day identified in a 90-day oral toxicity study in rats, the margin of exposure is at least 2500.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=90a9d8a8450bdf4d; raw_unit=mg/kg bw per day; context=Overall, it can be concluded that the NOAEL was 2500 mg/kg bw per day (i.e.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =246 mg/kg bw/day - - 13-week Subchronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0ff43bb245ee3789; raw_unit=mg/kg bw per day; context=Therefore, the NOAEL was identified as 246 mg/kg bw per day as TOS, the highest dose tested in the 13-week study.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =50 mg/kg bw/day - - - Developmental toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c611713045f4189e; raw_unit=mg/kg bw per day; context=The NOAEL for this study is considered to be 50 mg/kg bw per day, based on the available summarized information reported in SCCNFP (2004). (b) Developmental toxicity No information on the developmental toxicity of Quinoline Yellow was available.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =3750 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=712fc0fa18afa4ac; raw_unit=mg/kg bw per day; context=males at the highest tested dose compared with control animals, it was less than 10%, a value not considered to be biologically significant; the no-observed- adverse-effect level (NOAEL) for this study is therefore considered to be 25 000 mg/kg diet (equivalent to 3750 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2250 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d5614ea2581c08de; raw_unit=mg/kg bw per day; context=However, based on deaths and a body weight decrement relative to the controls at 50 000 mg/kg diet, the NOAEL for the study is 15 000 mg/kg diet (equivalent to 2250 mg/kg bw per day) (USFDA, 1986). (b) Rat Sunset Yellow FCF (FD&C Yellow No.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =1250 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0b0ba72d1c3dea85; raw_unit=mg/kg bw per day; context=As the body weight decrement among males at the highest dose was less than 10%, a value not considered to be biologically significant, the NOAEL for this study is considered to be 25 000 mg/kg diet (equivalent to 1250 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =1500 mg/kg bw/day - oral chronic Chronic toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=0376572d806e6510; raw_unit=mg/kg bw per day; context=Hence, the NOAEL for the chronic phase of the study is 30 000 mg/kg diet (equivalent to 1500 mg/kg bw per day) (USFDA, 1986).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =375 mg/kg bw/day - oral - Reproductive toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9f5da0aa9580e98c; raw_unit=mg/kg bw per day; context=Hence, the NOAEL for reproductive toxicity is 7500 mg/kg diet (equivalent to 375 mg/kg bw per day) (USFDA, 1986).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =6000 mg/kg bw/day - oral - Developmental toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=4405d7cfb1691081; raw_unit=mg/kg; context=Hence, in the absence of any effects on the reproductive parameters and inconsistent neurological outcomes, it can be concluded that the NOAEL for this study is 6000 mg/kg in the diet (approximately 1000 mg/kg bw per day), the highest dose tested (Tanaka, 1996). (b) Developmental toxicity No information on the developmental toxicity of Sunset Yellow FCF was available.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =4.5 mg/kg bw/day Rat - 13-week Reproductive toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=de1f19ebcd59a617; raw_unit=mg/kg bw; context=The Committee of Experts on Flavouring Substances of the Council of Europe (CoE, 2005) established a temporary maximum daily intake of 0.023 mg/ kg bw based on a NOAEL of 4.5 mg/kg bw from a 13-week study showing adverse reproductive effects on male rats, applying a safety factor of 200.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a26fd9d6716f88e4; raw_unit=mg/kg bw per day; context=A NOAEL of 2.7 mg/kg bw per day was determined based on a statistically significant decrease in relative cauda epididymis weight at the next higher dose level (NTP, 1993;
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6ff0fa3a66a1bb5f; raw_unit=mg/kg bw per day; context=Based on reported behavioural changes and decreased thyroid hormones, the LOAEL and NOAEL 240 Cyanogenic glycosides (addendum) values identified for this study are 1.2 and 0.7 mg/kg bw per day, as cyanide, respectively (Jackson, 1988).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=15bf57925953355f; raw_unit=mg/kg bw per day; context=le daily intake (PMTDI) for fumonisins B1 (FB1), B2 (FB2) and B3 (FB3), alone or in combination, of 2 ug/kg body weight (bw) on the basis of the no- observed-adverse-effect level (NOAEL) of 0.2 mg/kg bw per day for kidney toxicity and application of an uncertainty factor of 100.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.005 mg/kg bw Rat - - Acute toxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=e11f5a628c3ab783; raw_unit=ug/kg bw.; unit_normalization=converted from micrograms; context=Thus, the single-dose NOAEL for apoptosis in male Wistar rat liver would be below 5 ug/kg bw.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =45 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f4cd1603e3e9f526; raw_unit=mg/kg bw per day; context=As only one dose was tested, a NOAEL could not be determined by the Committee, but would be below 45 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =2.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=91b2adfc47cad8b8; raw_unit=mg/kg bw per day; context=The NOAEL was 2.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=1 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=f13bf9a5eeb2d922; raw_unit=mg/kg bw per day; context=In a previous study using a similar experimental design, the NOAEL for liver toxicity was greater than 1 mg/kg bw per day (Annex 1, reference 153, Table 5).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =4.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a5fbaa03d7f24578; raw_unit=mg/kg bw per day; context=The Committee concluded that, based on reduced body weight gain at and above 11.4 mg/kg bw per day, the NOAEL was 4.2 mg/kg bw per day, whereas for induction of GSTP+ foci, it was 11.4 mg/kg bw per day, and for lipid peroxidation, it was 21 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =15 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=934cb72de292e8cf; raw_unit=mg/kg bw per day; context=A NOAEL could Fumonisins (addendum) 347 not be determined by the Committee, as all treatment groups showed either liver pathology or reduced weight gains, but would be lower than 15 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.11 mg/kg bw/day Rat oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=a8ae0ed8293f3da3; raw_unit=mg/kg bw per day; context=er and kidney and the lack of any apparent time-dependent increase in sphinganine or sphinganine 1-phosphate in rats consuming the 1.1 mg/kg diet, the Committee concluded that the NOAEL was 0.11 mg/kg bw per day and that the LOAEL was 1.35 mg/kg bw per day (for total fumonisins).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.03 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=6359a7700c7e4b56; raw_unit=mg/kg bw per day; context=hology scores and the close correlation between fumonisin exposure, the pathology scores and the levels of total sphingoid bases and sphingoid base 1-phosphates in rat kidney, the NOAEL in this study could be 0.03 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.02 mg/kg bw/day Rabbit oral 24 weeks Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=8d45c093febf19e8; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL was the dose of the control group, 0.02 mg/kg bw per day. (iii) Rabbits Crossbred male rabbits (22-24 weeks old, 1.36 ± 0.01 kg, 10 animals per group) were fed diets prepared with maize that had been inoculated with F. verticillioides MRC 826 at silking in the field.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.04 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c92617afbeccdb5b; raw_unit=mg/ kg bw per day; context=The authors Fumonisins (addendum) 363 concluded that the data indicated a NOAEL of 1 mg/kg diet, equivalent to 0.04 mg/ kg bw per day (Zomborszky-Kovács et al., 2002a,b).
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.4 mg/kg bw/day - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=c01018654903ff7d; raw_unit=mg/kg bw per day; context=The NOAEL was 10 mg FB1 and FB2 per kilogram diet, equivalent to 0.4 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =0.01 mg/kg bw/day - oral 28 days Neurotoxicity document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=4beabb7c2ed8c10b; raw_unit=mg/kg bw per day; context=The Committee determined that the NOAEL (intravenous) after 28 days for clinically defined neurological signs was 0.01 mg/kg bw per day. (vi) Other species Mule ducks (7 days old) were gavaged for 77 days with F. verticillioides (NRRL 34281) culture extract that was partially purified and contained FB1 at doses of 0, 2, 8, 32 and 128 mg/kg feed.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL =8 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7a7a6ce3f47cfe3f; raw_unit=mg/kg diet; context=The NOAEL was 8 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg diet - oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d6be8b1934342874; raw_unit=mg/kg diet; context=The NOAEL was greater than 20 mg/kg diet.
INCHEM_WHO_jecfa_jecmono_v65je01 NOAEL >=20 mg/kg bw/day Mouse intraperitoneal 2 days Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=7e5b290b3ff6e32e; raw_unit=mg/kg bw per day; context=The NOAEL for HFB1-induced NTDs and liver toxicity in mice is greater than 20 mg/kg bw per day when dosed for 2 days intraperitoneally.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =25 mg/kg bw/day Mouse oral long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=2d95ceaa5bdf00c7; raw_unit=mg/kg bw per day; context=s eighteenth meeting, the Committee considered an additional long-term feeding study in mice that had become available and revised the temporary ADI to 0-0.125 mg/kg bw based on a NOEL of 25 mg/kg bw per day (this NOEL assumed 500 mg/kg in the diet to be equivalent to 25 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =500 mg/kg bw/day Rat - long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9452780729fdaaf2; raw_unit=mg/kg bw per day; context=The Committee noted that the long-term study in rats showed no adverse effects in the kidneys and had a NOEL of 500 mg/kg bw per day based on reduced body weight gain at higher doses.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =375 mg/kg bw/day Mouse oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d9139e62007515ed; raw_unit=mg/kg bw per day; context=The ADI was derived by applying a 100-fold safety factor to the higher NOEL from the mouse dietary study, which was equivalent to 375 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL range:1000-15001500 mg/kg bw/day Mouse oral long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=ca9d2e2245da6c6b; raw_unit=mg/kg bw per day; context=The Committee established an ADI of 0-10 mg/kg bw based on a NOEL of 10 000 mg/kg in the diet (equivalent to a range of 1000-1500 mg/kg bw per day) in the long-term study in mice.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =25 mg/kg bw/day Mouse oral long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=2d95ceaa5bdf00c7; raw_unit=mg/kg bw per day; context=s eighteenth meeting, the Committee considered an additional long-term feeding study in mice that had become available and revised the temporary ADI to 0-0.125 mg/kg bw based on a NOEL of 25 mg/kg bw per day (this NOEL assumed 500 mg/kg in the diet to be equivalent to 25 mg/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =500 mg/kg bw/day Rat - long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=9452780729fdaaf2; raw_unit=mg/kg bw per day; context=The Committee noted that the long-term study in rats showed no adverse effects in the kidneys and had a NOEL of 500 mg/kg bw per day based on reduced body weight gain at higher doses.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL =375 mg/kg bw/day Mouse oral - Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=d9139e62007515ed; raw_unit=mg/kg bw per day; context=The ADI was derived by applying a 100-fold safety factor to the higher NOEL from the mouse dietary study, which was equivalent to 375 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v65je01 NOEL range:1000-15001500 mg/kg bw/day Mouse oral long-term Toxicology study document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=ca9d2e2245da6c6b; raw_unit=mg/kg bw per day; context=The Committee established an ADI of 0-10 mg/kg bw based on a NOEL of 10 000 mg/kg in the diet (equivalent to a range of 1000-1500 mg/kg bw per day) in the long-term study in mice.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.012 mg/kg bw/day Pig oral - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=af26a9adb0225f0a; raw_unit=mg/kg bw; context=For acute exposure, it referred to the then current edition of the WHO Guidelines for Drinking-water Quality, which derived a TDI of 0.012 mg/kg bw, applying an uncertainty factor of 100 to a lowest-observed-adverse-effect level (LOAEL) of 1.2 mg/kg bw in a study in pigs showing functional thyroid changes.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.045 mg/kg bw/day Rat oral subchronic Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=65dd64f31e9c3cfb; raw_unit=mg/kg bw per day; context=Based on a reported NOAEL for cyanide of 4.5 mg/kg bw per day from the subchronic study described above in which rats were exposed to sodium cyanide through drinking-water, a TDI for cyanide of 0.045 mg/kg bw per day was derived.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.002 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=5fe2f1c29b551951; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The Committee established a group provisional maximum tolerable daily intake (PMTDI) for fumonisins B1 (FB1), B2 (FB2) and B3 (FB3), alone or in combination, of 2 ug/kg body weight (bw) on the basis of the no- observed-adverse-effect level (NOAEL) of 0.2 mg/kg bw per day for kidney toxicity and application of an uncertainty factor of 100.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.012 mg/kg bw/day Pig oral - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=af26a9adb0225f0a; raw_unit=mg/kg bw; context=For acute exposure, it referred to the then current edition of the WHO Guidelines for Drinking-water Quality, which derived a TDI of 0.012 mg/kg bw, applying an uncertainty factor of 100 to a lowest-observed-adverse-effect level (LOAEL) of 1.2 mg/kg bw in a study in pigs showing functional thyroid changes.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.045 mg/kg bw/day Rat oral subchronic Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=65dd64f31e9c3cfb; raw_unit=mg/kg bw per day; context=Based on a reported NOAEL for cyanide of 4.5 mg/kg bw per day from the subchronic study described above in which rats were exposed to sodium cyanide through drinking-water, a TDI for cyanide of 0.045 mg/kg bw per day was derived.
INCHEM_WHO_jecfa_jecmono_v65je01 TDI =0.002 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v65je01; title=WHO Additives Series 65: Safety Evaluation of Certain Food Additives and Contaminants; path=mirror/documents/jecfa/jecmono/v65je01.pdf; row_hash=5fe2f1c29b551951; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The Committee established a group provisional maximum tolerable daily intake (PMTDI) for fumonisins B1 (FB1), B2 (FB2) and B3 (FB3), alone or in combination, of 2 ug/kg body weight (bw) on the basis of the no- observed-adverse-effect level (NOAEL) of 0.2 mg/kg bw per day for kidney toxicity and application of an uncertainty factor of 100.
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4978; row=10053; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Yellow 6; preferred_name=FD&C Yellow 6; dtxsid=DTXSID6021456; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021456; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4980; row=10054; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Yellow 6; preferred_name=FD&C Yellow 6; dtxsid=DTXSID6021456; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021456; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 18.9 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2374; Record_ID=adme_parameters_1016; Data_Type=Measured; DTXSID=DTXSID6021456; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=18.9; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021456
NTP_ICE_adme_parameters Fu 1.38e-7 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2375; Record_ID=adme_parameters_1016; Data_Type=Measured; DTXSID=DTXSID6021456; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.38e-07; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021456
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=6828; Record_ID=cancer_992; Data_Type=WOE; Formulation_Name=FD&C Yellow 6; Mixture=Chemical; DTXSID=DTXSID6021456; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/26; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021456
NTP_ICE_cancer Top dose 25000 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=6827; Record_ID=cancer_993; Data_Type=In Vivo; Formulation_Name=FD & C yellow No. 6; Mixture=Chemical; DTXSID=DTXSID6021456; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=25000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-208; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr208/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021456
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9332; RecordID=ARPathway2016_1095; DatasetName=ARPathway2016; DTXSID=DTXSID6021456; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021456; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021456
ToxRefDB_ToxRefDB_v3_pod.csv 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =625 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 12 week SUB study_id=6347; toxval_study_source_id=studyid6347_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-bone marrow-hyperplasia; dose_level=2; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =900 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 12 week SUB study_id=6348; toxval_study_source_id=studyid6348_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=1; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =3750 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=6351; toxval_study_source_id=studyid6351_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL >1250 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 2 year CHR study_id=6352; toxval_study_source_id=studyid6352_Adult_F0_F_NA; dose_level=2; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LOAEL =2500 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 12 week SUB study_id=6347; toxval_study_source_id=studyid6347_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=4; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LOAEL =15000 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 12 week SUB study_id=6348; toxval_study_source_id=studyid6348_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=5; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =300 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 12 week SUB study_id=6347; toxval_study_source_id=studyid6347_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-bone marrow-hyperplasia|in life observation-body weight-body weight; dose_level=1; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL >0 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 12 week SUB study_id=6348; toxval_study_source_id=studyid6348_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=0; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =1875 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 2 year CHR study_id=6351; toxval_study_source_id=studyid6351_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =625 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 2 year CHR study_id=6352; toxval_study_source_id=studyid6352_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NOAEL =1250 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 12 week SUB study_id=6347; toxval_study_source_id=studyid6347_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-bone marrow-hyperplasia|in life observation-body weight-body weight gain; dose_level=3; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NOAEL =7500 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 12 week SUB study_id=6348; toxval_study_source_id=studyid6348_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=4; study_year=1980; study_citation=(1980) CARCINOGENESIS BIOASSAY OF FD and C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); dsstox_substance_id=DTXSID6021456; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ECHA_IUCLID 23 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =19700 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836402_15836403_15845298_15845299_15850871_15851020:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06b107e4ac1aec841c92f201fa1a028d
ToxValDB_ECHA_IUCLID LOAEL =1200 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839531_15846590_15848543_15848783:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6a0279ac7b7563419202b5f0fac9bcad
ToxValDB_ECHA_IUCLID LOAEL =2400 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839532_15846591_15848515_15848799:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d9790f04e8c10529602724810d52acc
ToxValDB_ECHA_IUCLID LOAEL =1170 mg/kg bw/day Rat oral chronic; 64 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15849368:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fcdd9000eb037f399e5b309d351f9232
ToxValDB_ECHA_IUCLID LOAEL =600 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7dc0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/9/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15859999_15860000:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_74278df43bc28aab8afc9dbe5a6afdc5
ToxValDB_ECHA_IUCLID LOEL =1000 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead96e4b0a7c65d1c4e8a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833290_15850856:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b26ee1364cf6b03de1c6a8716843e140
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d230363; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/9/3?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823107_15824409:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7e46fa8409b6b12b6a1396d8d804d49
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bc9d7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824406:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a7c6543ad78052cd1a380427b23cd1c5
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bc9da; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824408:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_266cc8c7a4f7eef540ba61bc4de1d718
ToxValDB_ECHA_IUCLID NOAEL =9850 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836402_15836403_15845298_15845299_15850871_15851020:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_739c6de3baa1e9b833563071e10331f1
ToxValDB_ECHA_IUCLID NOAEL =148 mg/kg bw/day Mouse oral chronic; 80 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2562; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12236?documentUUID=99b7317c-4c1d-4b46-8d69-c269b8cd8271; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=body weight and weight gain|haematology|histopathology: neoplastic|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837826_15840410_15849369_15849370:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_caea783c002ec8c8226c168416bd7c71
ToxValDB_ECHA_IUCLID NOAEL =1152 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839532_15846591_15848515_15848799:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca7c4fca0ec15e61fe7696e98b94a9db
ToxValDB_ECHA_IUCLID NOAEL =576 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839531_15846590_15848543_15848783:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dec337092c1c916ac4006c75e64fa70b
ToxValDB_ECHA_IUCLID NOAEL =2960 mg/kg bw/day Mouse oral chronic; 80 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70ba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837826_15840410_15849369_15849370:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5997f3f0ad679d175ca4f6c8940dbbd5
ToxValDB_ECHA_IUCLID NOAEL =1250 mg/kg bw/day Rat oral chronic; 103 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebde4b0a7c65d1caac3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/17287?documentUUID=2b8c51d8-385d-41fd-af3c-2fa778d851b0; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15849743:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03d262e95e95b00512c9fcf3dbf516c8
ToxValDB_ECHA_IUCLID NOAEL =2500 mg/kg bw/day Rat oral chronic; 103 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebde4b0a7c65d1caac3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/17287?documentUUID=2b8c51d8-385d-41fd-af3c-2fa778d851b0; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15849744:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_675f8903ec8b33f642c74acb37252e61
ToxValDB_ECHA_IUCLID NOAEL =2000 mg/kg bw/day Rat oral chronic; 80 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead96e4b0a7c65d1c4e86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15850855:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34fd1e475327ce06f8a45c6c49051224
ToxValDB_ECHA_IUCLID NOAEL <1182 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae06e4b0a7c65d1c70b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/6/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836402_15836403_15845298_15845299_15850871_15851020:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0823a4e1582a4a068225de9e3e3b55e3
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7dbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/9/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857151_15857761_15860484_15862101_15862663:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d7c368596aa8d7612fd6c8c6b09b19c
ToxValDB_ECHA_IUCLID NOAEL =100000 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7dcc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/9/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15857501:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9701d76eed8ea4f0d7038b7a701c571a
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7dc0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11604/7/9/2?documentUUID=17a6d5cd-1cbd-41b3-b200-263e0a0215cb; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15860704:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f37c8dc11fd51f26cfab79f60f9a559a
ToxValDB_ECHA_IUCLID NOAEL =750 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaa7e4b0a7c65d1b6e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: food efficiency|P0: haematology|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857151_15857761_15860484_15862101_15862663:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e7ce51c3a172ff6796da04a72c706a5
ToxValDB_ECHA_IUCLID NOEL =500 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead96e4b0a7c65d1c4e8a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11727?documentUUID=5a724af6-0466-4f1f-86fb-50cc3253ca1c; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833290_15850856:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c464a1015d6511676dacbda98e83bd71
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =2000 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602349:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07055a14aa20e19fd4227d5b8d3ea3d9
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =500 mg/kg bw/day Dog oral chronic; 7 years chronic LONG_REF=EFSA ANS (2009). Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive. doi:10.2903/j.efsa.2009.1330.; TITLE=Scientific Opinion on the re-evaluation of Sunset Yellow FCF (E 110) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2009.1330; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614326:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9022bda5c6dbb0d4371abe7ab5431b8f
ToxValDB_EFSA NOAEL =375 mg/kg bw/day Rat oral short-term; 28 days reproduction developmental LONG_REF=EFSA ANS (2014). Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E110). doi:10.2903/j.efsa.2014.3765.; TITLE=Reconsideration of the temporary ADI and refined exposure assessment for Sunset Yellow FCF (E110); AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2014.3765; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614327:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fcc66a001da7210a1abd26bbd3cc99d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1469.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631643:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f1595f02ffe109b71e760db9cbf75dbe
ToxValDB_HPVIS 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS LOAEL =1950 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=NTP (1981) National Toxicology Program. Carcinogenesis Bioassay of FD & C Yellow No. 6. NTP 80-33.).Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=1; EXTERNAL_SOURCE_ID=62006; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639121_15639261:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6969910fa1a1bf9d2a3c706995bab751
ToxValDB_HPVIS LOAEL =4625 mg/kg bw/day Mouse oral chronic; 103 weeks chronic LONG_REF=NTP (1981) National Toxicology Program. Carcinogenesis Bioassay of FD & C Yellow No. 6. NTP 80-33.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=1; EXTERNAL_SOURCE_ID=63314; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639391_15639481:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76764f96313d86430eac9f53bbe4813f
ToxValDB_HPVIS LOAEL =300 mg/kg bw/day Rat oral short-term; 10 days developmental LONG_REF=International Research and Development Corporation (1972) Teratology study in rats. Compound FD&C Yellow No. 6. Unpublished report no. 306-004.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=2; EXTERNAL_SOURCE_ID=59960; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1974; ORIGINAL_YEAR=1974; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642922_15642923:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdd7b3225a8189728fd83cd81cf78285
ToxValDB_HPVIS NOAEL =975 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=NTP (1981) National Toxicology Program. Carcinogenesis Bioassay of FD & C Yellow No. 6. NTP 80-33.).Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=1; EXTERNAL_SOURCE_ID=60949; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639121_15639261:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_39318ddd4dbeb415c307308d62e2ecf3
ToxValDB_HPVIS NOAEL =2312.5 mg/kg bw/day Mouse oral chronic; 103 weeks chronic LONG_REF=NTP (1981) National Toxicology Program. Carcinogenesis Bioassay of FD & C Yellow No. 6. NTP 80-33.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=1; EXTERNAL_SOURCE_ID=64087; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639391_15639481:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7ae6b986fa74fec2abecbb20ea67b796
ToxValDB_HPVIS NOAEL =100 mg/kg bw/day Rat oral short-term; 10 days developmental LONG_REF=International Research and Development Corporation (1972) Teratology study in rats. Compound FD&C Yellow No. 6. Unpublished report no. 306-004.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2007; QUALITY=2; EXTERNAL_SOURCE_ID=59959; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1974; ORIGINAL_YEAR=1974; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642922_15642923:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_79d8bb2e382994021c8c235ddea2aae8
ToxValDB_HPVIS NOAEL =1500 mg/kg bw/day Rat oral chronic; 126 days reproduction developmental LONG_REF=Bio/dynamics Inc. (1981) First Long-Term In-Utero Study in Rats (Study No. 77-1778)Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2006; QUALITY=1; EXTERNAL_SOURCE_ID=65384; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS:15643205:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2170aa4536738c996a53af3861f5ea64
ToxValDB_ToxRefDB 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =625 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6347; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-bone marrow-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711476_15711477_15711478_15711479:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c58d37fcfbcbffd9b1a4c7c724b4c4bb
ToxValDB_ToxRefDB LEL =900 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6348; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711484_15711485_15711486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70e0edf292224f37380ab4a15a5b1a83
ToxValDB_ToxRefDB LEL =3750 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6351; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711489_15711490:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5bbeda39bbf7903c7f4b76113c8f036a
ToxValDB_ToxRefDB LOAEL =2500 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6347; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711476_15711477_15711478_15711479:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_070ba4387ad5cc813528ca8bfc7b2fc2
ToxValDB_ToxRefDB LOAEL =15000 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6348; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711484_15711485_15711486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ac389b9a9dfc0f44f2ca48fa626e7a4
ToxValDB_ToxRefDB NEL =300 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6347; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711476_15711477_15711478_15711479:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1d7ebe00796ce7a7459c46e3e4e44a8
ToxValDB_ToxRefDB NEL =1875 mg/kg bw/day Mouse oral chronic; 2 years chronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6351; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711489_15711490:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b3ed4e36a8c7312e33808a7371a8583
ToxValDB_ToxRefDB NEL =625 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Chronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6352; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711496_15711497_15711498_15711499:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9329be1a1a1774dfd433ea0582fecbca
ToxValDB_ToxRefDB NOAEL =1250 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6347; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711476_15711477_15711478_15711479:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01df53957b5207c7c68cb5b1fddabd73
ToxValDB_ToxRefDB NOAEL =7500 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic LONG_REF=(1980) CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0). NTP 80-33, NIH Publication Number 81-1764. (Subchronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF FD & C YELLOW NO. 6 (CAS NO. 2783-94-0); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6348; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711484_15711485_15711486:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cadd23d591b110cdbc6e4d39f7ab1984
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H77VEI93A8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H10N2O7S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H77VEI93A8"}
openFDA substances FDA UNII substance identifier H77VEI93A8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H10N2O7S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H77VEI93A8"}
openFDA substances FDA UNII substance identifier H77VEI93A8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H10N2O7S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H77VEI93A8"}
openFDA substances FDA UNII substance identifier H77VEI93A8 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H10N2O7S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H77VEI93A8"}