NOAEL Studies Fragrance

Cinnamic Acid NOAEL Studies

INCI: CINNAMIC ACID

CAS: 140-10-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Fu 0.0499 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1997; Record_ID=adme_parameters_2084; Data_Type=Measured; DTXSID=DTXSID5022489; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0499; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022489
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 25.8317108495128 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8744; RecordID=ERPathway2016_233; DatasetName=ERPathway2016; DTXSID=DTXSID5022489; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=25.8317108495128; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022489
NTP_ICE_endocrine ACC 14.93932984748 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8745; RecordID=ERPathway2016_233; DatasetName=ERPathway2016; DTXSID=DTXSID5022489; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=14.93932984748; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022489
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8740; RecordID=ARPathway2016_825; DatasetName=ARPathway2016; DTXSID=DTXSID5022489; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022489
NTP_ICE_endocrine Model Score 0.101 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8746; RecordID=ERPathway2016_233; DatasetName=ERPathway2016; DTXSID=DTXSID5022489; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.101; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022489
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier U14A832J8D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U14A832J8D"}
openFDA substances FDA UNII substance identifier U14A832J8D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U14A832J8D"}
openFDA substances FDA UNII substance identifier U14A832J8D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U14A832J8D"}
openFDA substances FDA UNII substance identifier U14A832J8D UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U14A832J8D"}