NOAEL Studies Fragrance

Cinnamyl Alcohol NOAEL Studies

INCI: CINNAMYL ALCOHOL

CAS: 104-54-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =275 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2017 - OutputID 2920 - clinical chemistry - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =275 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2017 - OutputID 2920 - clinical chemistry - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_421; row=16193; data_type=In Vivo; mixture=Chemical; chemical_name=3-Phenyl-2-propen-1-ol; preferred_name=3-Phenyl-2-propen-1-ol; dtxsid=DTXSID9041491; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491; source_file=acute_oral.xlsx
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 62.9650975954467 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3250; RecordID=ERPathway2016_414; DatasetName=ERPathway2016; DTXSID=DTXSID9041491; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=62.9650975954467; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_endocrine ACC 42.079892248649 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3251; RecordID=ERPathway2016_414; DatasetName=ERPathway2016; DTXSID=DTXSID9041491; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=42.079892248649; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3246; RecordID=ARPathway2016_448; DatasetName=ARPathway2016; DTXSID=DTXSID9041491; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_endocrine Model Score 0.00786 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=3252; RecordID=ERPathway2016_414; DatasetName=ERPathway2016; DTXSID=DTXSID9041491; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00786; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization 168 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 196.6 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2115; Record_ID=skin_sensitization_invitro_525; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=196.6; Reported_Response_Unit=ug/mL; Response=196.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD54, EC200 97 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2484; Record_ID=skin_sensitization_invitro_598; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=97; Reported_Response_Unit=ug/mL; Response=97; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD86, EC150 101.6 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2114; Record_ID=skin_sensitization_invitro_525; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=101.6; Reported_Response_Unit=ug/mL; Response=101.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD86, EC150 73 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2482; Record_ID=skin_sensitization_invitro_598; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=73; Reported_Response_Unit=ug/mL; Response=73; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD86, EC150 147 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2493; Record_ID=skin_sensitization_invitro_601; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=147; Reported_Response_Unit=ug/mL; Response=147; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD86, EC150 76.803 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8215; Record_ID=skin_sensitization_invitro_2238; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=572.4; Reported_Response_Unit=uM; Conversion_Factor_Value=134.178; Conversion_Factor_Source=EPA Dashboard; Converted_Response=76.803; Converted_Response_Unit=ug/mL; Response=76.803; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CD86, EC150 21.41 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8602; Record_ID=skin_sensitization_invitro_2377; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=21.41; Reported_Response_Unit=ug/mL; Response=21.41; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CV70 109.71 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8601; Record_ID=skin_sensitization_invitro_2377; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=U-SENS; Endpoint=CV70; Reported_Response=109.71; Reported_Response_Unit=ug/mL; Response=109.71; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CV75 350 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2116; Record_ID=skin_sensitization_invitro_525; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CV75; Reported_Response=350; Reported_Response_Unit=ug/mL; Response=350; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization CV75 206.9 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=2486; Record_ID=skin_sensitization_invitro_598; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=h-CLAT; Endpoint=CV75; Reported_Response=206.9; Reported_Response_Unit=ug/mL; Response=206.9; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses range4.2 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2357; Record_ID=skin_sensitization_invivo_667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response_Modifier=range; Response=4.2 - 5.0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 4.167 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2365; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=4.167; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 2.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2373; Record_ID=skin_sensitization_invivo_669; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 5.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2381; Record_ID=skin_sensitization_invivo_670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=5.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 1.786 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2389; Record_ID=skin_sensitization_invivo_671; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.786; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 1.389 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2397; Record_ID=skin_sensitization_invivo_672; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.389; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 2.167 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2431; Record_ID=skin_sensitization_invivo_678; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.167; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 2.333 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2439; Record_ID=skin_sensitization_invivo_679; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 14 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2463; Record_ID=skin_sensitization_invivo_683; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=14; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 1.65 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2485; Record_ID=skin_sensitization_invivo_686; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.65; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 5.75 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2500; Record_ID=skin_sensitization_invivo_687; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=5.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1981; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 7.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2509; Record_ID=skin_sensitization_invivo_690; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=7.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2517; Record_ID=skin_sensitization_invivo_689; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 5.4 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2524; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=5.4; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 8.1 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2534; Record_ID=skin_sensitization_invivo_693; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=8.1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 4.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2535; Record_ID=skin_sensitization_invivo_692; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=4.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 4 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2355; Record_ID=skin_sensitization_invivo_667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 3.333 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2363; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=3.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 10 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2379; Record_ID=skin_sensitization_invivo_670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=10; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 1.429 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2387; Record_ID=skin_sensitization_invivo_671; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.429; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 1.111 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2395; Record_ID=skin_sensitization_invivo_672; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.111; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 1.667 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2429; Record_ID=skin_sensitization_invivo_678; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2449; Record_ID=skin_sensitization_invivo_681; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2481; Record_ID=skin_sensitization_invivo_686; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Concentration, one positive response 2 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2520; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=2; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Cys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=359; Record_ID=skin_sensitization_invitro_113; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Cys 21.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=367; Record_ID=skin_sensitization_invitro_115; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=21.3; Reported_Response_Unit=%; Response=21.3; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Lys 15.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=357; Record_ID=skin_sensitization_invitro_113; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=15.1; Reported_Response_Unit=%; Response=15.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Lys 2.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=365; Record_ID=skin_sensitization_invitro_115; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.7; Reported_Response_Unit=%; Response=2.7; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Lys 2.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=372; Record_ID=skin_sensitization_invitro_116; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.1; Reported_Response_Unit=%; Response=2.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Lys + Cys 7.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=361; Record_ID=skin_sensitization_invitro_113; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=7.6; Reported_Response_Unit=%; Response=7.6; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Depletion Lys + Cys 12 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=369; Record_ID=skin_sensitization_invitro_115; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=12; Reported_Response_Unit=%; Response=12; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 104.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4107; Record_ID=skin_sensitization_invitro_937; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=104.1; Reported_Response_Unit=uM; Response=104.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 106.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4109; Record_ID=skin_sensitization_invitro_938; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=106.6; Reported_Response_Unit=uM; Response=106.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 107.47 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4111; Record_ID=skin_sensitization_invitro_939; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=107.47; Reported_Response_Unit=uM; Response=107.47; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 110.32 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4113; Record_ID=skin_sensitization_invitro_940; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=110.32; Reported_Response_Unit=uM; Response=110.32; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 110.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4115; Record_ID=skin_sensitization_invitro_941; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=110.7; Reported_Response_Unit=uM; Response=110.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 117.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4117; Record_ID=skin_sensitization_invitro_943; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=117.3; Reported_Response_Unit=uM; Response=117.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 118.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4119; Record_ID=skin_sensitization_invitro_944; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=118.2; Reported_Response_Unit=uM; Response=118.2; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 121.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4121; Record_ID=skin_sensitization_invitro_945; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=121.1; Reported_Response_Unit=uM; Response=121.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 123.6 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4123; Record_ID=skin_sensitization_invitro_946; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=123.56100000000001; Reported_Response_Unit=uM; Response=123.6; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 125.92 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4125; Record_ID=skin_sensitization_invitro_947; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=125.92; Reported_Response_Unit=uM; Response=125.92; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 130.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4127; Record_ID=skin_sensitization_invitro_949; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=130.9; Reported_Response_Unit=uM; Response=130.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 142.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4129; Record_ID=skin_sensitization_invitro_950; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=142.63999999999999; Reported_Response_Unit=uM; Response=142.6; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 157.09 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4131; Record_ID=skin_sensitization_invitro_951; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=157.09; Reported_Response_Unit=uM; Response=157.09; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 160.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4133; Record_ID=skin_sensitization_invitro_952; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=160.19999999999999; Reported_Response_Unit=uM; Response=160.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 189.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4135; Record_ID=skin_sensitization_invitro_954; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=189.1; Reported_Response_Unit=uM; Response=189.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 190.92 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4137; Record_ID=skin_sensitization_invitro_955; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=190.92; Reported_Response_Unit=uM; Response=190.92; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 24 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4139; Record_ID=skin_sensitization_invitro_956; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=24; Reported_Response_Unit=uM; Response=24; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 59.55 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4141; Record_ID=skin_sensitization_invitro_957; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=59.55; Reported_Response_Unit=uM; Response=59.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 61.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4143; Record_ID=skin_sensitization_invitro_959; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=61.3; Reported_Response_Unit=uM; Response=61.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 70.47 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4145; Record_ID=skin_sensitization_invitro_960; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=70.47; Reported_Response_Unit=uM; Response=70.47; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 82.65 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4147; Record_ID=skin_sensitization_invitro_961; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=82.65; Reported_Response_Unit=uM; Response=82.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 83.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4149; Record_ID=skin_sensitization_invitro_962; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=83.7; Reported_Response_Unit=uM; Response=83.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 86.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4151; Record_ID=skin_sensitization_invitro_963; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=86.3; Reported_Response_Unit=uM; Response=86.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 87 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4153; Record_ID=skin_sensitization_invitro_964; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=87; Reported_Response_Unit=uM; Response=87; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 >2000 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4155; Record_ID=skin_sensitization_invitro_965; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 100.18 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4205; Record_ID=skin_sensitization_invitro_966; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=100.18; Reported_Response_Unit=uM; Response=100.18; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC1.5 <168.79 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7584; Record_ID=skin_sensitization_invitro_1826; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=168.79; Reported_Response_Unit=uM; Response=168.79; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC3 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4157; Record_ID=skin_sensitization_invitro_946; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization EC3 21 % Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12874; Record_ID=skin_sensitization_invivo_492; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=LLNA; Endpoint=EC3; Response=21; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1174 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4159; Record_ID=skin_sensitization_invitro_956; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1173.9000000000001; Reported_Response_Unit=uM; Response=1174; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1289 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4160; Record_ID=skin_sensitization_invitro_965; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1288.6099999999999; Reported_Response_Unit=uM; Response=1289; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1566.03 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4162; Record_ID=skin_sensitization_invitro_943; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1566.03; Reported_Response_Unit=uM; Response=1566.03; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1583.46 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4164; Record_ID=skin_sensitization_invitro_964; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1583.46; Reported_Response_Unit=uM; Response=1583.46; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 774.6 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4166; Record_ID=skin_sensitization_invitro_946; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=774.6; Reported_Response_Unit=uM; Response=774.6; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1705.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4168; Record_ID=skin_sensitization_invitro_937; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1705.3; Reported_Response_Unit=uM; Response=1705.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1726.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4170; Record_ID=skin_sensitization_invitro_938; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1726.3; Reported_Response_Unit=uM; Response=1726.3; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1757.57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4172; Record_ID=skin_sensitization_invitro_960; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1757.57; Reported_Response_Unit=uM; Response=1757.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1827.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4174; Record_ID=skin_sensitization_invitro_963; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1827.8; Reported_Response_Unit=uM; Response=1827.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1857.83 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4176; Record_ID=skin_sensitization_invitro_961; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1857.83; Reported_Response_Unit=uM; Response=1857.83; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1870.04 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4178; Record_ID=skin_sensitization_invitro_940; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1870.04; Reported_Response_Unit=uM; Response=1870.04; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1991.57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4180; Record_ID=skin_sensitization_invitro_950; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1991.57; Reported_Response_Unit=uM; Response=1991.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 1996.22 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4182; Record_ID=skin_sensitization_invitro_957; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1996.22; Reported_Response_Unit=uM; Response=1996.22; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization IC50 >420 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7657; Record_ID=skin_sensitization_invitro_1826; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=420; Reported_Response_Unit=uM; Response=420; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.442 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4202; Record_ID=skin_sensitization_invitro_965; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4419999999999999; Reported_Response_Unit=Unitless; Response=1.442; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.635 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4204; Record_ID=skin_sensitization_invitro_959; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.635; Reported_Response_Unit=Unitless; Response=1.635; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.648 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4206; Record_ID=skin_sensitization_invitro_952; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.6479999999999999; Reported_Response_Unit=Unitless; Response=1.648; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.7 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4207; Record_ID=skin_sensitization_invitro_938; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7; Reported_Response_Unit=Unitless; Response=1.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.705 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4209; Record_ID=skin_sensitization_invitro_962; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7050000000000001; Reported_Response_Unit=Unitless; Response=1.705; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.75 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4211; Record_ID=skin_sensitization_invitro_946; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.75; Reported_Response_Unit=Unitless; Response=1.75; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.756 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4213; Record_ID=skin_sensitization_invitro_955; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.756; Reported_Response_Unit=Unitless; Response=1.756; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.935 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4215; Record_ID=skin_sensitization_invitro_957; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9350000000000001; Reported_Response_Unit=Unitless; Response=1.935; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 1.993 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4217; Record_ID=skin_sensitization_invitro_954; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.9930000000000001; Reported_Response_Unit=Unitless; Response=1.993; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 10.8 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4219; Record_ID=skin_sensitization_invitro_937; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=10.8; Reported_Response_Unit=Unitless; Response=10.8; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 11.381 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4221; Record_ID=skin_sensitization_invitro_951; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=11.381; Reported_Response_Unit=Unitless; Response=11.381; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 12.5 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4223; Record_ID=skin_sensitization_invitro_945; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=12.500999999999999; Reported_Response_Unit=Unitless; Response=12.5; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 14.708 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4225; Record_ID=skin_sensitization_invitro_960; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=14.708; Reported_Response_Unit=Unitless; Response=14.708; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 17.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4227; Record_ID=skin_sensitization_invitro_963; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.100000000000001; Reported_Response_Unit=Unitless; Response=17.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 17.282 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4229; Record_ID=skin_sensitization_invitro_940; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.282; Reported_Response_Unit=Unitless; Response=17.282; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 18.03 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4231; Record_ID=skin_sensitization_invitro_941; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.027999999999999; Reported_Response_Unit=Unitless; Response=18.03; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 19.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4233; Record_ID=skin_sensitization_invitro_961; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.295999999999999; Reported_Response_Unit=Unitless; Response=19.3; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 6.339 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4235; Record_ID=skin_sensitization_invitro_939; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.3390000000000004; Reported_Response_Unit=Unitless; Response=6.339; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 6.727 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4237; Record_ID=skin_sensitization_invitro_943; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.7270000000000003; Reported_Response_Unit=Unitless; Response=6.727; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 64.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4239; Record_ID=skin_sensitization_invitro_956; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=64.099999999999994; Reported_Response_Unit=Unitless; Response=64.1; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 7.061 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4241; Record_ID=skin_sensitization_invitro_947; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.0609999999999999; Reported_Response_Unit=Unitless; Response=7.061; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 7.784 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4243; Record_ID=skin_sensitization_invitro_964; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.7839999999999998; Reported_Response_Unit=Unitless; Response=7.784; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 7.894 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4245; Record_ID=skin_sensitization_invitro_966; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.8940000000000001; Reported_Response_Unit=Unitless; Response=7.894; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 7.984 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4247; Record_ID=skin_sensitization_invitro_950; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.984; Reported_Response_Unit=Unitless; Response=7.984; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 8.6 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4249; Record_ID=skin_sensitization_invitro_944; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.6; Reported_Response_Unit=Unitless; Response=8.6; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 9.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4251; Record_ID=skin_sensitization_invitro_949; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.1; Reported_Response_Unit=Unitless; Response=9.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Imax 7.283 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7560; Record_ID=skin_sensitization_invitro_1826; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=LuSens; Endpoint=Imax; Reported_Response=7.282774663; Reported_Response_Unit=Unitless; Response=7.283; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2345; Record_ID=skin_sensitization_invivo_665; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90152-7|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses range3.3 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2353; Record_ID=skin_sensitization_invivo_667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response_Modifier=range; Response=3.3 - 4.0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 12 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2361; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=12; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 20 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2369; Record_ID=skin_sensitization_invivo_669; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=20; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 9.091 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2377; Record_ID=skin_sensitization_invivo_670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=9.091; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 28 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2385; Record_ID=skin_sensitization_invivo_671; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=28; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 36 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2393; Record_ID=skin_sensitization_invivo_672; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=36; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 23.08 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2427; Record_ID=skin_sensitization_invivo_678; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=23.08; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 21.43 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2435; Record_ID=skin_sensitization_invivo_679; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=21.43; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 3.571 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2459; Record_ID=skin_sensitization_invivo_683; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=3.571; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 30.3 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2478; Record_ID=skin_sensitization_invivo_686; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=30.3; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 8.696 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2491; Record_ID=skin_sensitization_invivo_687; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=8.696; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1981; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 14.29 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2508; Record_ID=skin_sensitization_invivo_689; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=14.29; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 3.704 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2516; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=3.704; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 11.11 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2525; Record_ID=skin_sensitization_invivo_692; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=11.11; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Incidence of positive responses 2.667 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2552; Record_ID=skin_sensitization_invivo_690; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 2483 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2344; Record_ID=skin_sensitization_invivo_665; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2483; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90152-7|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2348; Record_ID=skin_sensitization_invivo_666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 2400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2352; Record_ID=skin_sensitization_invivo_667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 6750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2360; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 8250 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2434; Record_ID=skin_sensitization_invivo_679; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=8250; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 4724 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2514; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4724; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 4500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2541; Record_ID=skin_sensitization_invivo_695; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area 4000 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2550; Record_ID=skin_sensitization_invivo_690; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses range3000 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2358; Record_ID=skin_sensitization_invivo_667; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response_Modifier=range; Response=3000 - 3636; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2813 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2366; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2813; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1688 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2374; Record_ID=skin_sensitization_invivo_669; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1688; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 3712.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2382; Record_ID=skin_sensitization_invivo_670; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=3712.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1205 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2390; Record_ID=skin_sensitization_invivo_671; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1205; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 937.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2398; Record_ID=skin_sensitization_invivo_672; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=937.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1788 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2432; Record_ID=skin_sensitization_invivo_678; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1788; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1925 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2440; Record_ID=skin_sensitization_invivo_679; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1925; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 4538 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2452; Record_ID=skin_sensitization_invivo_681; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4538; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 11550 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2464; Record_ID=skin_sensitization_invivo_683; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=11550; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1114 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2487; Record_ID=skin_sensitization_invivo_686; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1114; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 8100 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2501; Record_ID=skin_sensitization_invivo_688; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=8100; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 4744 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2504; Record_ID=skin_sensitization_invivo_687; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4744; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1981; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 7500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2511; Record_ID=skin_sensitization_invivo_690; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=7500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2888 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2519; Record_ID=skin_sensitization_invivo_689; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2888; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 6378 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2526; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=6378; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 3713 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2538; Record_ID=skin_sensitization_invivo_692; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=3713; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 2250 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2364; Record_ID=skin_sensitization_invivo_668; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=2250; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1350 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2372; Record_ID=skin_sensitization_invivo_669; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 964.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2388; Record_ID=skin_sensitization_invivo_671; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=964.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2396; Record_ID=skin_sensitization_invivo_672; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1375 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2430; Record_ID=skin_sensitization_invivo_678; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1375; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 4125 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2450; Record_ID=skin_sensitization_invivo_681; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=4125; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1980; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 675 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2483; Record_ID=skin_sensitization_invivo_686; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=675; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1000 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2507; Record_ID=skin_sensitization_invivo_690; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=1000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 2063 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2515; Record_ID=skin_sensitization_invivo_689; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=2063; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 2362 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2522; Record_ID=skin_sensitization_invivo_691; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=2362; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 2750 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2532; Record_ID=skin_sensitization_invivo_692; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=2750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Max stimulation index 5.7 ratio Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12873; Record_ID=skin_sensitization_invivo_492; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=LLNA; Endpoint=Max stimulation index; Response=5.7; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2347; Record_ID=skin_sensitization_invivo_665; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1974; Not available; 10.1016/0015-6264(74)90152-7|Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2351; Record_ID=skin_sensitization_invivo_666; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1979; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Bickers et al. 2005; 15811570; 10.1016/j.fct.2004.09.013|Letizia et al. 2005; 15811571; 10.1016/j.fct.2004.09.012|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
NTP_ICE_skin_sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2536; Record_ID=skin_sensitization_invivo_693; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041491; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Steltenkamp et al. 1980; 7461523; 10.1016/0015-6264(80)90200-x|Akkan et al. 2003; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041491
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/6/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|organ weights and organ / body weight ratios|urinalysis|body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|ophthalmological examination; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15832940:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e409be65b65e56ace9624410fa41868
ToxValDB_ECHA_IUCLID NOAEL >=350 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5281; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/29451/7/9/2?documentUUID=fd058317-fd62-4e91-9e50-3103bc6268fc; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=F1: viability|F1: sexual maturation|F1: clinical signs|F1: mortality|F1: body weight and weight gain|F1: clinical biochemistry|F1: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|development|gross pathology|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15861614:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6224a724eee5637d87440eedaf0bc984
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =275 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2017). Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species. doi:10.2903/j.efsa.2017.4672.; TITLE=Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2017.4672; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15621606:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_380bac17a7d35da9e4c61779799f5650
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2.64 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630736:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_793e758591b37d1cd3af2d2dd7e0b02f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier SS8YOP444F UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SS8YOP444F"}
openFDA substances FDA UNII substance identifier SS8YOP444F UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SS8YOP444F"}
openFDA substances FDA UNII substance identifier SS8YOP444F UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SS8YOP444F"}
openFDA substances FDA UNII substance identifier SS8YOP444F UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SS8YOP444F"}