Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Cocamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3.25 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 0.3 other | dermal | rat | dermal | REACH |
| LOAEL | 62.5 other | oral | rat | oral | REACH |
| NOAEL | ca.10 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 12.5 other | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3.25 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 62.5 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.10 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Primary fatty amine with GHS H315 (skin irritation) and H318 (serious eye damage) hazards; must be formulated at appropriate dilution with concentration-dependent irritation; CPSR must address use level justification.
Frequently Asked Questions
Is Cocamine safe in cosmetics?
Primary fatty amine with GHS H315 (skin irritation) and H318 (serious eye damage) hazards; must be formulated at appropriate dilution with concentration-dependent irritation; CPSR must address use level justification. The EU classifies Cocamine as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Cocamine allowed in the EU?
Cocamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocamine do in cosmetics?
Cocamine functions as: Antistatic agent, Surfactant - Emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 61788-46-3.
What is the Margin of Safety for Cocamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cocamine?
The NOAEL (No Observed Adverse Effect Level) for Cocamine is 3.25 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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