Good Cosmetic Ingredient NOAEL Data

Cocoyl Sarcosine

INCI: COCOYL SARCOSINE

CAS Number
68411-97-2
Function
Surfactant – cleansing agent; hair conditioning agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA permitted. CIR: safe as used when formulated to be non-irritating; must not form N-nitroso compounds

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Cocoyl Sarcosine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=2 other oral rat oral REACH
LOAEL 100 mg/kg bw/day oral rat oral REACH
NOAEL >=2 other oral - oral REACH

Expert Verdict

Secondary amine with potential to form N-nitrososarcosine; do not use with nitrosating agents; fatty acid composition varies with coconut oil source

⚠️
Concern Level: Low

Regulatory Flags

epa_safer_alternative

Frequently Asked Questions

Is Cocoyl Sarcosine safe in cosmetics?

Secondary amine with potential to form N-nitrososarcosine; do not use with nitrosating agents; fatty acid composition varies with coconut oil source The EU classifies Cocoyl Sarcosine as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Cocoyl Sarcosine allowed in the EU?

Cocoyl Sarcosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cocoyl Sarcosine do in cosmetics?

Cocoyl Sarcosine functions as: Surfactant – cleansing agent; hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 68411-97-2.

What is the Margin of Safety for Cocoyl Sarcosine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cocoyl Sarcosine?

The NOAEL (No Observed Adverse Effect Level) for Cocoyl Sarcosine is >=2 other based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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