Excellent Emollient NOAEL Data

Alkyl Benzoate

INCI: C12-15 ALKYL BENZOATE

CAS Number
68411-27-8
Function
Emollient; skin-conditioning agent; UV filter dispersant
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR (2012) safe as used; 971 VCRP uses; up to 59% in leave-on products

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Alkyl Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1200 mg/kg bw/day oral rat oral REACH
NOAEL >8 other oral rat oral REACH
NOAEL 2 other oral rat oral REACH
NOAEL >8 other oral rat oral REACH
NOAEL 2 other oral rat oral REACH
NOAEL >=1000 mg/kg bw/day oral dog oral REACH
NOAEL >=1000 mg/kg bw/day oral dog oral REACH

Expert Verdict

CAS 68411-27-8. EU: Permitted with no restrictions. US: CIR (2012) safe as used. Not genotoxic, not a sensitizer, not a reproductive toxicant. Excellent safety profile.

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Concern Level: None

Regulatory Flags

cir-safe-2012 low-dermal-absorption uv-filter-dispersant

Frequently Asked Questions

Is Alkyl Benzoate safe in cosmetics?

CAS 68411-27-8. EU: Permitted with no restrictions. US: CIR (2012) safe as used. Not genotoxic, not a sensitizer, not a reproductive toxicant. Excellent safety profile. The EU classifies Alkyl Benzoate as "permitted". Safety rating: EXCELLENT. 7 toxicological study endpoint(s) are available in our database.

Is Alkyl Benzoate allowed in the EU?

Alkyl Benzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alkyl Benzoate do in cosmetics?

Alkyl Benzoate functions as: Emollient; skin-conditioning agent; UV filter dispersant. It is classified as a Emollient in our database. CAS number: 68411-27-8.

What is the Margin of Safety for Alkyl Benzoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Alkyl Benzoate?

The NOAEL (No Observed Adverse Effect Level) for Alkyl Benzoate is >=1200 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.

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