Is Copper Carbonate Hydroxide safe in cosmetics?
Copper Carbonate Hydroxide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Copper Carbonate Hydroxide
Also known as: Copper II carbonate, (Carbonato)dihydroxydicopper, (Carbonato(2-))dihydroxydicopper, Caswell No. 235, Copper carbonate, basic (+7 more)
INCI: COPPER CARBONATE HYDROXIDE
Copper Carbonate Hydroxide (CAS 12069-69-1) is a cosmetic cosmetic ingredient functioning as Antimicrobial and pigment in makeup applications. Reported NOAEL =78 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 12069-69-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Copper Carbonate Hydroxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332, H315, H319, H335, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial and pigment in makeup applications
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
FDA 21 CFR 582.80 — generally recognized as safe (GRAS) as a nutrient/dietary supplement. No specific FDA cosmetics restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Copper Carbonate Hydroxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Copper Carbonate Hydroxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =78 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =185 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantEnvironmental Hazard
Hazard Class and Category
Acute Tox. 4; Acute Tox. 4; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H332 Harmful if inhaled
- H302 Harmful if swallowed
- H319 Causes serious eye irritation
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 1.2 mg/L dusts or mists; oral: ATE = 500.0 mg/kg bw; M = 10; M = 10
Inserted via ATP: ATP17
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Pigment
Preservative
Expert Verdict
Expert safety assessment and concern-level summary for Copper Carbonate Hydroxide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Copper Carbonate Hydroxide by CAS number or substance name.
Studies
2
Lowest NOAEL
78 mg/kg bw/day
Highest NOAEL
185 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Copper II carbonate
(Carbonato)dihydroxydicopper
(Carbonato(2-))dihydroxydicopper
Caswell No. 235
Copper carbonate, basic
EINECS 235-113-6
EPA Pesticide Chemical Code 022901
Kop karb
Carbonic acid, copper complex
Cuprum carbonicum
UNII-GIK928GH0Y
Dikupfer(II)-carbonat-dihydroxid
Chemical Function
Pigment
Preservative
Biocide
Regulatory Lists
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
Canada; consumer_product; Substances in Products - Canada (4/2014)
Europe; supplements
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Copper Carbonate Hydroxide allowed in the EU?
Copper Carbonate Hydroxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Copper Carbonate Hydroxide do in cosmetics?
Copper Carbonate Hydroxide functions as: Antimicrobial and pigment in makeup applications. It is classified as a cosmetic ingredient in our database. CAS number: 12069-69-1.
What is the NOAEL for Copper Carbonate Hydroxide?
The NOAEL (No Observed Adverse Effect Level) for Copper Carbonate Hydroxide is =78 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Copper Carbonate Hydroxide used outside cosmetics?
Copper Carbonate Hydroxide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Copper Carbonate Hydroxide have different safety status in cosmetics vs industrial chemicals?
Copper Carbonate Hydroxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332, H315, H319, H335, H400, H410).
Compliance Tools
Check Copper Carbonate Hydroxide compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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