Good Cosmetic Ingredient NOAEL Data

Curry Red (CI 16035)

INCI: CURRY RED (CI 16035)

CAS Number
25956-17-6
Function
Colorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 0.4%
🇺🇸 US Status permitted
US Notes FDA approved (FD&C Red 40); permitted in food, drugs, and cosmetics except eye area

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Curry Red (CI 16035). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 250 mg/kg bw/day oral dog Short Term Toxicity COSMOS_DB
NOAEL 5190 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2595 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2595 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7785 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 2595 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7785 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 2595 mg/kg bw/day oral rat Reproductive-developmental COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 2595 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB

Expert Verdict

Azo dye with cresidine sulfonic acid as primary metabolite from azo cleavage; SCCNFP identified percutaneous absorption study shortcomings; purity must meet E 129 and Commission Directive 95/45/EC criteria; Ames test positive under reductive conditions with inadequate in vivo micronucleus testing.

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Concern Level: Low

Regulatory Flags

colorant eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Curry Red (CI 16035) safe in cosmetics?

Azo dye with cresidine sulfonic acid as primary metabolite from azo cleavage; SCCNFP identified percutaneous absorption study shortcomings; purity must meet E 129 and Commission Directive 95/45/EC criteria; Ames test positive under reductive conditions with inadequate in vivo micronucleus testing. The EU classifies Curry Red (CI 16035) as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Curry Red (CI 16035) allowed in the EU?

Curry Red (CI 16035) EU regulatory status: permitted. Maximum allowed concentration: 0.4%. This is based on EU Regulation 1223/2009 and its amendments.

What does Curry Red (CI 16035) do in cosmetics?

Curry Red (CI 16035) functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 25956-17-6.

What is the Margin of Safety for Curry Red (CI 16035)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Curry Red (CI 16035)?

The NOAEL (No Observed Adverse Effect Level) for Curry Red (CI 16035) is 250 mg/kg bw/day based on a Short Term Toxicity study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Curry Red (CI 16035) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
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