Is CYANOCOBALAMIN safe in cosmetics?
CYANOCOBALAMIN has a safety rating of "GOOD" in our database. EU status: permitted.
GOOD
Cosmetic Ingredient
CYANOCOBALAMIN
Also known as: 1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-, monoester with cobinamide cyanide, inner salt, 5,6-Dimethylbenzimidazolyl cyanocobamide, 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide, Cobalamin (vitamin B12), 1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-alpha-D-ribofuranosyl)-, monoester with cobinamide cyanide hydroxide, inner salt (+14 more)
CYANOCOBALAMIN (CAS 68-19-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Skin Conditioning
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
cobalt(3+);[(2R,3S,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate;cyanide
InChIKey
FDJOLVPMNUYSCM-SYUKHSAKSA-L
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CYANOCOBALAMIN across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Pharmaceutical
Softener and conditioner
Thickening agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for CYANOCOBALAMIN — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
fda_food_additive
Known Synonyms
1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-, monoester with cobinamide cyanide, inner salt
5,6-Dimethylbenzimidazolyl cyanocobamide
5,6-Dimethylbenzimidazolyl-Co-cyanocobamide
Cobalamin (vitamin B12)
1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-alpha-D-ribofuranosyl)-, monoester with cobinamide cyanide hydroxide, inner salt
Bevatine-12
BRN 4122889
Cobamide, alpha-5,6-dimethyl-1H-benzimidazolyl-, cyanide
Cobinamide, cyanide hydroxide, dihydrogen phosphate
Cobinamide, cyanide hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobione
Coobalamed
Cosmo-Rey
Crystimin-1000
Cynobal
5,6-Dimethylbenzimidazolylcobamide cyanide
Dimethylbenzimidazoylcobamide
Distivit (B12 peptide)
EINECS 200-680-0
Chemical Function
Softener and conditioner
Flavouring and nutrient
Pharmaceutical
Thickening agent
Regulatory Lists
pharmaceutical
Europe; supplements
Europe; food_additive; supplements
Canada; pharmaceutical
Canada; pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
cyanocobalamin
ChEMBL ID
CHEMBL2110563
Adverse Event Associations
12148
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Cyanocobalamin
Food Category
preservative
Frequently Asked Questions
Is CYANOCOBALAMIN allowed in the EU?
CYANOCOBALAMIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CYANOCOBALAMIN do in cosmetics?
CYANOCOBALAMIN functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68-19-9.
Is CYANOCOBALAMIN used outside cosmetics?
CYANOCOBALAMIN also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CYANOCOBALAMIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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