CYANOCOBALAMIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
8 study endpoints found for CYANOCOBALAMIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.02 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 0.1 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 3 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 0.02 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 0.1 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 3 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| LOAEL | 5620 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 100 mg/kg bw/day | intravenous | rat | other | REACH |
Expert Verdict
CYANOCOBALAMIN is listed in the EU CosIng database with functions: Skin Conditioning It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is CYANOCOBALAMIN safe in cosmetics?
CYANOCOBALAMIN is listed in the EU CosIng database with functions: Skin Conditioning It is permitted in the EU without specific restrictions. The EU classifies CYANOCOBALAMIN as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is CYANOCOBALAMIN allowed in the EU?
CYANOCOBALAMIN EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CYANOCOBALAMIN do in cosmetics?
CYANOCOBALAMIN functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68-19-9.
What is the NOAEL for CYANOCOBALAMIN?
The NOAEL (No Observed Adverse Effect Level) for CYANOCOBALAMIN is 0.02 mg/kg bw/day based on a Reproductive study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check CYANOCOBALAMIN compliance across multiple jurisdictions:
Related Ingredients
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