Cyclic Adenosine Diphosphate Ribose (cADPR)

INCI: CYCLIC ADENOSINE DIPHOSPHATE RIBOSE

CAS Number
123548-30-9 (commonly cited for cADPR as a biochemical; cosmetic databases often omit CAS)
Function
Skin-conditioning, cell-signaling modulator, anti-aging active; regulates intracellular calcium release
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA position; viewed as a novel cosmetic active; manufacturer must provide safety substantiation for intended concentration and exposure

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Generally well-tolerated; possible mild stinging, warmth, or temporary redness; rare allergic contact dermatitis reported; potential for cumulative irritation when layered with strong acids or retinoids

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Concern Level: Low

Frequently Asked Questions

Is Cyclic Adenosine Diphosphate Ribose (cADPR) safe in cosmetics?

Generally well-tolerated; possible mild stinging, warmth, or temporary redness; rare allergic contact dermatitis reported; potential for cumulative irritation when layered with strong acids or retinoids The EU classifies Cyclic Adenosine Diphosphate Ribose (cADPR) as "permitted". Safety rating: GOOD.

Is Cyclic Adenosine Diphosphate Ribose (cADPR) allowed in the EU?

Cyclic Adenosine Diphosphate Ribose (cADPR) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclic Adenosine Diphosphate Ribose (cADPR) do in cosmetics?

Cyclic Adenosine Diphosphate Ribose (cADPR) functions as: Skin-conditioning, cell-signaling modulator, anti-aging active; regulates intracellular calcium release. It is classified as a cosmetic ingredient in our database. CAS number: 123548-30-9 (commonly cited for cADPR as a biochemical; cosmetic databases often omit CAS).

What is the Margin of Safety for Cyclic Adenosine Diphosphate Ribose (cADPR)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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