Cyclopropylbimatoprost

INCI: CYCLOPROPYLBIMATOPROST

CAS Number
1138395-12-6
Function
Eyelash conditioning (prostaglandin analogue derivative of bimatoprost)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically prohibited as a cosmetic ingredient, but bimatoprost itself is an FDA-approved drug (Latisse/Lumigan), which raises drug/cosmetic classification concerns if the analogue exerts pharmacological eyelash-growth activity.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Prostaglandin analogues can cause iris pigmentation changes, periorbital skin darkening, eye irritation, ocular hyperemia, and changes in eyelash pigmentation. Potential for systemic prostamide-receptor activity.. Synthetic N-cyclopropyl derivative of bimatoprost; designed to mimic prostaglandin effects on hair follicle cycling while attempting to circumvent drug classification

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Concern Level: Moderate

Frequently Asked Questions

Is Cyclopropylbimatoprost safe in cosmetics?

Prostaglandin analogues can cause iris pigmentation changes, periorbital skin darkening, eye irritation, ocular hyperemia, and changes in eyelash pigmentation. Potential for systemic prostamide-receptor activity.. Synthetic N-cyclopropyl derivative of bimatoprost; designed to mimic prostaglandin effects on hair follicle cycling while attempting to circumvent drug classification The EU classifies Cyclopropylbimatoprost as "prohibited". Safety rating: MODERATE.

Is Cyclopropylbimatoprost allowed in the EU?

Cyclopropylbimatoprost EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclopropylbimatoprost do in cosmetics?

Cyclopropylbimatoprost functions as: Eyelash conditioning (prostaglandin analogue derivative of bimatoprost). It is classified as a cosmetic ingredient in our database. CAS number: 1138395-12-6.

What is the Margin of Safety for Cyclopropylbimatoprost?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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