NOAEL Studies
Fragrance
D-Limonene NOAEL Studies
CAS: 5989-27-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =215 | mg/kg bw/day | Rat | oral: gavage | 721 days | chronic/long term toxicity | EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =250 | mg/kg bw/day | Mouse | - | - | - | EFSA FEEDAP - 2015 - OutputID 2784 - gross pathology - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species - doi:10.2903/j.efsa.2015.4053 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =215 | mg/kg bw/day | Rat | oral: gavage | 721 days | chronic/long term toxicity | EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =250 | mg/kg bw/day | Mouse | - | - | - | EFSA FEEDAP - 2015 - OutputID 2784 - gross pathology - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species - doi:10.2903/j.efsa.2015.4053 |
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx | NOAEL | =60 | mg/kg bw/day | Rat | - | - | reproduction toxicity | ENDPOINTSTUDY_ID 697582; TOX_ID 8346 - OP_ID 2558 - EFSA - 2014 - Conclusion on the peer review of the pesticide risk assessment of the active substance terpenoid blend QRD-460 - doi:10.2903/j.efsa.2014.3816 |
| EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx | NOAEL | =60 | mg/kg bw/day | Rat | - | - | reproduction toxicity | ENDPOINTSTUDY_ID 697582; TOX_ID 8346 - OP_ID 2558 - EFSA - 2014 - Conclusion on the peer review of the pesticide risk assessment of the active substance terpenoid blend QRD-460 - doi:10.2903/j.efsa.2014.3816 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"NB Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"56, 73"} |
INCHEM_WHO_cicads_cicads_cicad05 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_cicads_cicads_cicad05 | NOEL | =10 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad05; title=Limonene (CICADS); path=mirror/documents/cicads/cicads/cicad05.htm; row_hash=62e144bd6af9eed5; raw_unit=mg/kg body weight; context=The NOEL for effects in the liver was 10 mg/kg body weight; the no-observed-adverse-effect level (NOAEL) for effects in the liver was 30 mg/kg body weight per day. |
| INCHEM_WHO_cicads_cicads_cicad05 | NOEL | =0.1 | mg/kg bw/day | Human | oral | - | Toxicology study | document_id=cicads_cicads_cicad05; title=Limonene (CICADS); path=mirror/documents/cicads/cicads/cicad05.htm; row_hash=bb804d8d0d12ba5c; raw_unit=mg/kg body weight per day; context=Using uncertainty factors of 10 for intraspecies differences and 10 for interspecies differences, a tolerable intake for ingestion of d- limonene by humans of 0.1 mg/kg body weight per day may be calculated from the NOEL. |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8186; row=2080; data_type=In Vivo; mixture=Chemical; chemical_name=D-Limonene; preferred_name=D-Limonene; dtxsid=DTXSID1020778; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020778; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_8184; row=2081; data_type=In Vivo; mixture=Chemical; chemical_name=D-Limonene; preferred_name=D-Limonene; dtxsid=DTXSID1020778; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020778; source_file=acute_oral.xlsx |
NTP_ICE_cancer 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1370; Record_ID=cancer_2568; Data_Type=WOE; Formulation_Name=D-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/74; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_cancer | Top dose | 600 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1367; Record_ID=cancer_2570; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=600; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_cancer | Top dose | 150 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1371; Record_ID=cancer_2567; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_cancer | Top dose | 1000 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1373; Record_ID=cancer_2566; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_cancer | Top dose | 500 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1375; Record_ID=cancer_2565; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=500; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
NTP_ICE_skin_irritation 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | ET50 | 74.8 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=861; Record_ID=skin_irritation_invitro_1522; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=74.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 76.2 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=862; Record_ID=skin_irritation_invitro_1525; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=76.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 95.8 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=863; Record_ID=skin_irritation_invitro_1527; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=95.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 142 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=864; Record_ID=skin_irritation_invitro_1529; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=142; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 224 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=865; Record_ID=skin_irritation_invitro_1531; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=224; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 258 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=866; Record_ID=skin_irritation_invitro_1533; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=258; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 39.8 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=867; Record_ID=skin_irritation_invitro_1562; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=39.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 47.6 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=868; Record_ID=skin_irritation_invitro_1564; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=47.6; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | ET50 | 52.5 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=869; Record_ID=skin_irritation_invitro_1566; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=52.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 33.14 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=857; Record_ID=skin_irritation_invitro_1022; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=33.14; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 35 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=858; Record_ID=skin_irritation_invitro_1030; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=35; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 68.7 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=859; Record_ID=skin_irritation_invitro_1032; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=68.7; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 92.3 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=860; Record_ID=skin_irritation_invitro_1034; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=92.3; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 5.9 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=870; Record_ID=skin_irritation_invitro_1036; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=5.9; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 7.3 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=871; Record_ID=skin_irritation_invitro_1038; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 12.8 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=894; Record_ID=skin_irritation_invitro_1039; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.8; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 13.3 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=895; Record_ID=skin_irritation_invitro_1041; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=13.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 13.8 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=896; Record_ID=skin_irritation_invitro_1043; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=13.8; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 14 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=897; Record_ID=skin_irritation_invitro_1045; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=14; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 8.1 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=898; Record_ID=skin_irritation_invitro_1047; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.1; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 8.2 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=899; Record_ID=skin_irritation_invitro_1049; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.20; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 8.4 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=900; Record_ID=skin_irritation_invitro_1052; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.4; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 18.63 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=908; Record_ID=skin_irritation_invitro_1020; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=18.63; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 10.4 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=910; Record_ID=skin_irritation_invitro_1024; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=10.4; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 15 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=911; Record_ID=skin_irritation_invitro_1026; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=15; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability | 23.6 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=912; Record_ID=skin_irritation_invitro_1028; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=23.6; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability (18 hours) | 51 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=901; Record_ID=skin_irritation_invitro_211; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=51; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_irritation | Viability (42 hours) | 25.5 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=906; Record_ID=skin_irritation_invitro_211; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=25.5; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
NTP_ICE_skin_sensitization 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 216.7 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1731; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=216.7; Reported_Response_Unit=ug/mL; Response=216.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 278 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1698; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=278; Reported_Response_Unit=ug/mL; Response=278; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 30.03 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8676; Record_ID=skin_sensitization_invitro_2401; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=30.03; Reported_Response_Unit=ug/mL; Response=30.03; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8675; Record_ID=skin_sensitization_invitro_2401; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | CV75 | 736.6 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1712; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CV75; Reported_Response=736.6; Reported_Response_Unit=ug/mL; Response=736.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Depletion Cys | 18.6 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=264; Record_ID=skin_sensitization_invitro_76; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=18.6; Reported_Response_Unit=%; Response=18.6; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=235; Record_ID=skin_sensitization_invitro_76; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6264; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC1.5 | 4000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6266; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC3 | 69 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC3 | 69 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC3 | 69 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | EC3 | 69 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | IC50 | 118.1 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6270; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=118.1; Reported_Response_Unit=uM; Response=118.1; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | IC50 | 82.27 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6272; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=82.26686357; Reported_Response_Unit=uM; Response=82.27; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Imax | 1.14 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6274; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1399999999999999; Reported_Response_Unit=Unitless; Response=1.14; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Imax | 1.205 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6276; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.205020865; Reported_Response_Unit=Unitless; Response=1.205; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8713; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 4966 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8711; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4966; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
| NTP_ICE_skin_sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8718; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778 |
ToxRefDB_ToxRefDB_v3_pod.csv 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 103 week | CHR | study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =600 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 103 week | CHR | study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-body weight-body weight; dose_level=4; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =75 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 103 week | CHR | study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-hyperplasia|pathology microscopic-kidney-mineralization|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-adenoma/carcinoma combined|pathology microscopic-kidney-adenoma|in life observation-body weight-body weight; dose_level=1; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =500 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 103 week | CHR | study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =250 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 103 week | CHR | study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-multinucleated|pathology microscopic-liver-cytomegaly; dose_level=1; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =300 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 103 week | CHR | study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-mortality-mortality; dose_level=3; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 103 week | CHR | study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-adenoma/carcinoma combined|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-adenoma|in life observation-body weight-body weight|pathology microscopic-kidney-mineralization|pathology microscopic-kidney-hyperplasia; dose_level=0; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =3300 | mg/kg bw/day | Mouse | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d2241b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830046_15830047_15844787:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35f091971bf938f0507c65d48a2e4a49 |
| ToxValDB_ECHA_IUCLID | LOAEL | =1000 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d229728; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831207_15848173_15848768:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4c4bab7085331ca95c1abccf04e168d |
| ToxValDB_ECHA_IUCLID | LOAEL | =1200 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb02e4b0a7c65d224734; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832463_15847290_15848298:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ac2b71139fe73e88f17f4c608d28f23 |
| ToxValDB_ECHA_IUCLID | LOAEL | =1650 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca27e4b0a7c65d220922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832709_15832710_15839816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_716eb6214608ca1b81e54a0568ef47ff |
| ToxValDB_ECHA_IUCLID | LOAEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab7e4b0a7c65d223234; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836951_15842423_15847868_15848253:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06b45b4b58ea3f52e125323888949b0c |
| ToxValDB_ECHA_IUCLID | LOAEL | =3000 | mg/kg bw/day | Dog | oral | chronic; 6 months | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4fe4b0a7c65d2214f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838793_15842492_15850617_15850618:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_52b3d27b32b9cef3b32ff578a90f937e |
| ToxValDB_ECHA_IUCLID | NOAEL | >=75 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819966_15820520:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53b685a173f5146dbcbd541a3b00df8b |
| ToxValDB_ECHA_IUCLID | NOAEL | >=300 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819967_15820519:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3610f8e68601008613f514d1f74fae85 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=250 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820033_15820521:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35ad2ddd6042b4d8ab7a5d53f414292e |
| ToxValDB_ECHA_IUCLID | NOAEL | >=500 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820034_15820522:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5054a9d415b305a868b31c411d3d9fe6 |
| ToxValDB_ECHA_IUCLID | NOAEL | <=600 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819967_15820519:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_93eb2f3fa1de3279d79101f542a80169 |
| ToxValDB_ECHA_IUCLID | NOAEL | <=150 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819966_15820520:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_70d22329dc7ae943ef4c385a0b6d78cd |
| ToxValDB_ECHA_IUCLID | NOAEL | <=1000 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820034_15820522:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_449fecd245494677f64e4d85b83a45d4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =591 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230ba5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/9/3?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824983_15824984:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b3654cac178fae3bae916ad14b4f92d |
| ToxValDB_ECHA_IUCLID | NOAEL | =1650 | mg/kg bw/day | Mouse | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d2241b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830046_15830047_15844787:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ccf0bb3cafaed73c29c6de6b68cf297 |
| ToxValDB_ECHA_IUCLID | NOAEL | =825 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca27e4b0a7c65d220922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832709_15832710_15839816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70db390c0937fdcdb8ea5e48166ff471 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Dog | oral | chronic; 180 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb68e4b0a7c65d2260ee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/6/2?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=- |organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=-|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843767_15847179_15847651:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee63a31be6ee2ed9aeb6be3cc8a88c52 |
| ToxValDB_ECHA_IUCLID | NOAEL | =5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb68e4b0a7c65d2260ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/6/2?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836951_15842423_15847868_15848253:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ed6d473e8e14ff9f366789c755ad717 |
| ToxValDB_ECHA_IUCLID | NOAEL | =340 | mg/kg bw/day | Dog | oral | chronic; 6 months | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4fe4b0a7c65d2214f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838794_15842493_15850616:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f54a5ca660d1e37861d95886e4d8dd8 |
ToxValDB_ECOTOX 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =7.813 | mM | Mouse | oral | short-term; 24 days | short-term | LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596645_15596646_15599949:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1053df40e7df97a38bd0596be9e5682f |
| ToxValDB_ECOTOX | LOEL | =1 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e417694e1f94f35c0f652275bcabd68 |
| ToxValDB_ECOTOX | LOEL | =2 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Growth: Weight|Histology: Lesions|Injury: Adenoma; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1abd477c21eb94bd1015b4502b34a6c4 |
| ToxValDB_ECOTOX | LOEL | =41 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.99(2): 250-259 Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin 1989; TITLE=d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin; AUTHOR=Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey; DOI=10.1016/0041-008x(89)90007-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=159983; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Cytoplasmic inclusions; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598377_15598378:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d889da77c870b084bae332258496f9a3 |
| ToxValDB_ECOTOX | LOEL | =100000 | ppm | Mouse | dermal | chronic; 133 days | chronic | LONG_REF=Biomed. Pharmacother.63(9): 643-649 Arruda,D.C., D.C. Miguel, J.K.U. Yokoyama-Yasunaka, A.M. Katzin, and S.R.B. Uliana Inhibitory Activity of Limonene Against Leishmania Parasites In Vitro and In Vivo 2009; TITLE=Inhibitory Activity of Limonene Against Leishmania Parasites In Vitro and In Vivo; AUTHOR=Arruda,D.C., D.C. Miguel, J.K.U. Yokoyama-Yasunaka, A.M. Katzin, and S.R.B. Uliana; DOI=10.1016/j.biopha.2009.02.004; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160278; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Immunological: Amount or percent animals infested with parasites; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15598492:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bfcf7c153c88944f324cae4ea94610d5 |
| ToxValDB_ECOTOX | LOEL | =0.0001193 | mM | Mouse | oral | short-term; 28 days | short-term | LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Cell(s): T-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600224_15605073:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dd65a57272af37013504e43e6791df76 |
| ToxValDB_ECOTOX | LOEL | =250 | mg/kg bw/day | Rat | oral | acute; 0.0417 days | acute | LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Biochemistry: Phosphatidyl choline (phospholipid) content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600802:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aa0f15da09fa114e136ecb0eab084c5e |
| ToxValDB_ECOTOX | LOEL | =500 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=Food Chem. Toxicol.31(2): 125-136 Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds 1993; TITLE=Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90126-j; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601227_15601228:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7ae60b777b57ca26ce096b257360d7b2 |
| ToxValDB_ECOTOX | LOEL | =20000 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=Eur. J. Nutr.51:57-68 Santiago,J.V.A., J. Jayachitra, M. Shenbagam, and N. Nalini Dietary d-Limonene Alleviates Insulin Resistance and Oxidative Stress-Induced Liver Injury in High-Fat Diet and L-NAME-Treated Rats 2012; TITLE=Dietary d-Limonene Alleviates Insulin Resistance and Oxidative Stress-Induced Liver Injury in High-Fat Diet and L-NAME-Treated Rats; AUTHOR=Santiago,J.V.A., J. Jayachitra, M. Shenbagam, and N. Nalini; DOI=10.1007/s00394-011-0182-7; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=160159; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Enzyme(s): Aspartate aminotransferase|Hormone(s): Insulin|Morphology: Weight|Physiology: Systolic pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601297_15609066:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e2de0dce9e1d13a27ab9ddac245d1d9 |
| ToxValDB_ECOTOX | LOEL | =85 | mg/kg bw/day | Rat | oral | acute; 0.125 days | acute | LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603191_15603192:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6cc5ed50175ca313ca4571b59b1544af |
| ToxValDB_ECOTOX | LOEL | =50 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de75f0ec05f9b0f254669ee2e6c49649 |
| ToxValDB_ECOTOX | LOEL | =0.2 | mL | Mouse | dermal | chronic; 224 days | chronic | LONG_REF=Carcinogenesis7(12): 2047-2049 Elegbede,J.A., T.H. Maltzman, A.K. Verma, M.A. Tanner, C.E. Elson, and M.N. Gould Mouse Skin Tumor Promoting Activity of Orange Peel Oil and d-Limonene: A Re-Evaluation 1986; TITLE=Mouse Skin Tumor Promoting Activity of Orange Peel Oil and d-Limonene: A Re-Evaluation; AUTHOR=Elegbede,J.A., T.H. Maltzman, A.K. Verma, M.A. Tanner, C.E. Elson, and M.N. Gould; DOI=10.1093/carcin/7.12.2047; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=117947; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15609501:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1791324fae290614bf6ccdc32f61be9c |
| ToxValDB_ECOTOX | LOEL | =28.8 | mg/kg bw/day | Rat | oral | short-term; 7 days | subchronic | LONG_REF=- | Toxicology303:133-138 Brott,D.A., P. Bentley, M.V.P. Nadella, D. Thurman, J. Fikes, L. Cheatham, F. McGrath, W. Luo, and L.B. Kinter Renal Biomarker Changes Associated with Hyaline Droplet Nephropathy in Rats are Time and Potentially Compound Dependent 2013; TITLE=Renal Biomarker Changes Associated with Hyaline Droplet Nephropathy in Rats are Time and Potentially Compound Dependent; AUTHOR=Brott,D.A., P. Bentley, M.V.P. Nadella, D. Thurman, J. Fikes, L. Cheatham, F. McGrath, W. Luo, and L.B. Kinter; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=160109; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Abnormal kidney histopathology: hyalin droplet formation| mRNA expression of renal biomarkers; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15612935:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=7f0a031776c6b5fc4a6cef9cadae6407 |
| ToxValDB_ECOTOX | LOEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 45 days | subchronic | LONG_REF=- | Basic Clin. Pharmacol. Toxicol.112(3): 175-181 Murali,R., A. Karthikeyan, and R. Saravanan Protective Effects of d-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats 2013; TITLE=Protective Effects of d-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats; AUTHOR=Murali,R., A. Karthikeyan, and R. Saravanan; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160154; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=ROS: Decreased plasma thiobarbituric acid reactive substances (TBARS)|ROS: Decreased plasma lipid hydroperoxides (LOOH)| ROS: Decreased kidney conjugated dienes (CD) | Enzyme(s): Increased erythrocyte Glutathione peroxidase | Antioxidants: Increased plasma vitamin C | Antiodidants: Increased Liver Vitamin C | Antioxidants: Increased kidney Vitamin E | Antioxidants: Increased plasma GSH | Antioxidants: Increased Liver GSH | Antioxidants: Increased Kidney GSH; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15613453:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=0e2f4fba893022d9035f9a9c2b550d88 |
| ToxValDB_ECOTOX | LOEL | =75 | mg/kg bw/day | Rat | oral | short-term; 21 days | short-term | LONG_REF=- | Natl. Toxicol. Program Tech. Rep. Ser.347:167 p. Jameson,C.W. Toxicology and Carcinogenesis Studies of d-Limonene in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of d-Limonene in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=Jameson,C.W.; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160004; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Biochemistry: Alpha 2u-globulin; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613515:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=956ba73cc270bc802f6687e5c928a429 |
| ToxValDB_ECOTOX | NOEL | =125 | mM | Mouse | oral | subchronic; 56 days | subchronic | LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Cell(s): B-cell|Cell(s): T-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595033:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fff7635b3a5bff0a7cd64ba234c5c52d |
| ToxValDB_ECOTOX | NOEL | =0.4883 | mM | Mouse | oral | short-term; 24 days | short-term | LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596645_15596646_15599949:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c52605b1d3cdc0096791ca45c73a770b |
| ToxValDB_ECOTOX | NOEL | =0.5 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b94bc95afb9796624d9fa59614be46fc |
| ToxValDB_ECOTOX | NOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | LONG_REF=Toxicology258(2-3): 131-138 Borghoff,S.J., G.C. Hard, N.M. Berdasco, R. Gingell, S.M. Green, and W. Gulledge Methyl Isobutyl Ketone (MIBK) Induction of alpha2u-Globulin Nephropathy in Male, but Not Female Rats 2009; TITLE=Methyl Isobutyl Ketone (MIBK) Induction of alpha2u-Globulin Nephropathy in Male, but Not Female Rats; AUTHOR=Borghoff,S.J., G.C. Hard, N.M. Berdasco, R. Gingell, S.M. Green, and W. Gulledge; DOI=10.1016/j.tox.2009.01.018; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=118305; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Cell(s): Number of cells|Growth: Weight|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596950_15597267:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fe6855309643a23141a44da9bf6d2461 |
| ToxValDB_ECOTOX | NOEL | =14 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.99(2): 250-259 Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin 1989; TITLE=d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin; AUTHOR=Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey; DOI=10.1016/0041-008x(89)90007-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=159983; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Cytoplasmic inclusions; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598377_15598378:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=902f2772067c5de78d2b848db248b389 |
| ToxValDB_ECOTOX | NOEL | =4000 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=Food Chem. Toxicol.31(2): 125-136 Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds 1993; TITLE=Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90126-j; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Cell(s): Number of cells|Enzyme(s): Aspartate aminotransferase|Feeding behavior: Food consumption|Growth: Weight|Histology: Proliferation|Morphology: Organ weight in relationship to body weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECOTOX:15600131:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5177cf8e1274e7fbc82aa1046040f360 |
| ToxValDB_ECOTOX | NOEL | =25 | mg/kg bw/day | Rat | oral | acute; 0.125 days | acute | LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603191_15603192:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=20515b43e708f92123d19da9f8f67dc5 |
| ToxValDB_ECOTOX | NOEL | =200 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Biochemistry: Urea|Cell(s): Number of cells|Enzyme(s): (gamma) -glutamyl transferase|Feeding behavior: Food consumption|Growth: Weight|Injury: Occult blood|Morphology: Organ weight in relationship to body weight|Morphology: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|enzyme activity|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3df831ebdc1b0a30a1cbda1e1debfedc |
| ToxValDB_ECOTOX | NOEL | =10 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=88fd8e4fa2cd7e4a1c7d2b0dc331d884 |
| ToxValDB_ECOTOX | NOEL | =150 | mg/kg bw/day | Rat | oral | short-term; 5 days | short-term | LONG_REF=Food Chem. Toxicol.25(5): 345-353 Kanerva,R.L., G.M. Ridder, F.R. Lefever, and C.L. Alden Comparison of Short-Term Renal Effects Due to Oral Administration of Decalin or d-Limonene in Young Adult Male Fischer-344 Rats 1987; TITLE=Comparison of Short-Term Renal Effects Due to Oral Administration of Decalin or d-Limonene in Young Adult Male Fischer-344 Rats; AUTHOR=Kanerva,R.L., G.M. Ridder, F.R. Lefever, and C.L. Alden; DOI=10.1016/0278-6915(87)90167-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117976; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608757_15608758:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=156d4f8a450e1b1ea9eccc1e28b770d8 |
| ToxValDB_ECOTOX | NOEL | =50 | % | Mouse | dermal | short-term; 17 days | short-term | LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15610628:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b12828f8a09c346c9b8316f126b459d6 |
ToxValDB_EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =215 | mg/kg bw/day | Mouse | injection | - | repeat dose other | LONG_REF=EFSA CEF (2011). Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2011.2178.; TITLE=Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2011.2178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15621552:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7144e8e11664154e3b5332c69f575dd |
| ToxValDB_EFSA | NOAEL | =250 | mg/kg bw/day | Mouse | oral | - | repeat dose other | LONG_REF=EFSA FEEDAP (2015). Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species. doi:10.2903/j.efsa.2015.4053.; TITLE=Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2015.4053; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=EFSA:15621554:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b299f067e7c30bd370b179e38a66a6f |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =66.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633057:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_85f897c68361b2c9ecebb3b19d3d0efa |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <150 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e0ae4b0a676289df28a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Histopathology: Kidney-Nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=HESS:15638510:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_962afedee6eefa56e3a24e0e5f0f2657 |
ToxValDB_HPVIS 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =1000 | mg/kg bw/day | Mouse | oral | short-term; 13 days | short-term | LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=61676; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639779_15639994:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_280878b544ebcf941e271c11be8b34fb |
| ToxValDB_HPVIS | LOAEL | =600 | mg/kg bw/day | Rat | oral | short-term; 13 days | short-term | LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802. Tarone R.E. (1975) Tests for trend in life table analysis. Biometrika 62; 679-682. Cox D.R. (1972) Regression models and life tables. J.R. Stat. Soc. B34: 187-220.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=62175; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639861_15640113:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e12bfaef6a2a116dd500a623a5f87c13 |
| ToxValDB_HPVIS | LOAEL | =2770 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Kodama R., Tahara S., Sato K., Noda K., Ide H., Nishihara H. (1977b) Studies on d-limonene as a Gallstone Solubilizer Fine Structure of Liver, Kidneys and Blood Cells from Rats given d- limonene. Oyo Yakuri 13(6), 875.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62715; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639862_15639930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed3213b33ad16540fda25f5643f94283 |
| ToxValDB_HPVIS | LOAEL | =30 | mg/kg bw/day | Rat | oral | short-term; 13 days | short-term | LONG_REF=Webb D.R., Ridder M., and Alden C.L. (1989) Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62971; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639961_15640037:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ccc92deaefa55a6ea4bec14c6d5c821 |
| ToxValDB_HPVIS | LOAEL | =500 | mg/kg bw/day | Rabbit | oral | short-term; 13 days | reproduction developmental | LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings.Journal Oyo Yakuri, 13(6), 885-898.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=58047; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642328_15642808_15642817:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e5edd41fe69bb94bbf4e230cccb25f0 |
| ToxValDB_HPVIS | LOAEL | =2363 | mg/kg bw/day | Mouse | oral | short-term; 6 days | reproduction developmental | LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of mouse fetuses and offsprings. Journal Oyo Yakuri, 13(6), 885-898.; TITLE=Studies on d-limonene as a gallstone solubilizer: Effect on development of mouse fetuses and offsprings; AUTHOR=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T; QUALITY=2; EXTERNAL_SOURCE_ID=59613; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642579_15642696_15642810_15642945:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_169344cf8374573ef537aae5869b751e |
| ToxValDB_HPVIS | LOAEL | =2869 | mg/kg bw/day | Rat | oral | short-term; 7 days | developmental | LONG_REF=Tsuji M., Y.Fujisaki, Y.Arikawa, S.Masuda, S.Kinoshita, A.Okubo, K.Noda, H.Ide and Y.Iwanaga (1975b) Studies on d-limonene as a gallstone solubilizer: Effects on Development of Rat Fetuses and Offsprings. Journal Oyo Yakuri, 10(2), 179.; TITLE=Studies on d- limonene as a gallstone solubilizer: Effects on Development of Rat Fetuses and Offsprings; AUTHOR=Tsuji M., Y.Fujisaki, Y.Arikawa, S.Masuda, S.Kinoshita, A.Okubo, K.Noda, H.Ide and Y.Iwanaga; QUALITY=2; EXTERNAL_SOURCE_ID=59979; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642695_15642934:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e00ca0d28d867347da04cdcbd464ad1c |
| ToxValDB_HPVIS | NOAEL | =300 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.; TITLE=Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice; AUTHOR=National Toxicology Program; QUALITY=1; EXTERNAL_SOURCE_ID=62419; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639046_15639146_15639297:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b5276d26f0e89fde26000ac5ce2ef966 |
| ToxValDB_HPVIS | NOAEL | =1385 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Kodama R., Tahara S., Sato K., Noda K., Ide H., Nishihara H. (1977b) Studies on d-limonene as a Gallstone Solubilizer Fine Structure of Liver, Kidneys and Blood Cells from Rats given d- limonene. Oyo Yakuri 13(6), 875.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62176; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639862_15639930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3bf56b62ca08414c0f79f2b78f4696ef |
| ToxValDB_HPVIS | NOAEL | =500 | mg/kg bw/day | Mouse | oral | short-term; 13 days | short-term | LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=63230; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639779_15639994:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90c65ce7a407e64dd74b4df0de142861 |
| ToxValDB_HPVIS | NOAEL | =5 | mg/kg bw/day | Rat | oral | short-term; 13 days | short-term | LONG_REF=Webb D.R., Ridder M., and Alden C.L. (1989) Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=63489; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639961_15640037:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a532ef4aa0a923b548a1bffb6cf3eb2 |
| ToxValDB_HPVIS | NOAEL | >1000 | mg/kg bw/day | Rabbit | oral | short-term; 13 days | reproduction developmental | LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings. Journal Oyo Yakuri, 13(6), 885-898.; TITLE=Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings; AUTHOR=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T; QUALITY=2; EXTERNAL_SOURCE_ID=59612; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS:15642809:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_711a21f69026dc7cdad25ba24aa6b0e7 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | GFD7C86Q1W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"} |
| openFDA substances | FDA UNII substance identifier | GFD7C86Q1W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"} |
| openFDA substances | FDA UNII substance identifier | GFD7C86Q1W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"} |
| openFDA substances | FDA UNII substance identifier | GFD7C86Q1W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"} |