Darutoside

INCI: DARUTOSIDE

CAS Number
59219-65-7
Function
Triterpenoid glycoside from Siegesbeckia orientalis with skin-conditioning, anti-stretch mark, firming, and repair activity.
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not monographed by FDA; considered an active cosmetic ingredient and must not be marketed with drug claims unless compliant with drug regulations. Supplier SDS flags it as toxic and pharmaceutically active for research use only, which a CPSR must reconcile with cosmetic purity and grade.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Supplier SDS indicates possible risk of impaired fertility and harm to unborn child, plus skin and eye irritation potential; avoid use in pregnancy and breastfeeding or justify very low exposures, and treat as pharmacologically active with robust impurity and residual solvent control.

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Concern Level: High

Frequently Asked Questions

Is Darutoside safe in cosmetics?

Supplier SDS indicates possible risk of impaired fertility and harm to unborn child, plus skin and eye irritation potential; avoid use in pregnancy and breastfeeding or justify very low exposures, and treat as pharmacologically active with robust impurity and residual solvent control. The EU classifies Darutoside as "prohibited". Safety rating: MODERATE.

Is Darutoside allowed in the EU?

Darutoside EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Darutoside do in cosmetics?

Darutoside functions as: Triterpenoid glycoside from Siegesbeckia orientalis with skin-conditioning, anti-stretch mark, firming, and repair activity.. It is classified as a cosmetic ingredient in our database. CAS number: 59219-65-7.

What is the Margin of Safety for Darutoside?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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