Is Delta-Decalactone safe in cosmetics?
Delta-Decalactone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Delta-Decalactone
Also known as: 2H-Pyran-2-one, tetrahydro-6-pentyl-, 5-Decanolide, 5-Pentyl-5-pentanolide, Tetrahydro-6-pentyl-2H-pyran-2-one, δ-Decalactone (+15 more)
INCI: DELTA-DECALACTONE
Delta-Decalactone (CAS 705-86-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with creamy, peach, and coconut notes. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Fragrance ingredient with creamy, peach, and coconut notes
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
6-pentyloxan-2-one
InChIKey
GHBSPIPJMLAMEP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted under FEMA GRAS 2361; listed under 21 CFR 172.515 as a food flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Delta-Decalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Delta-Decalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Delta-Decalactone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
232
Source: WHO/JECFA
JECFA Evaluation
delta-DECALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Delta-Decalactone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Delta-Decalactone by CAS number or substance name.
Studies
2
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
COSMOS DB
Known Synonyms
2H-Pyran-2-one, tetrahydro-6-pentyl-
5-Decanolide
5-Pentyl-5-pentanolide
Tetrahydro-6-pentyl-2H-pyran-2-one
δ-Decalactone
δ-Amylvalerolactone
δ-Pentyl-δ-valerolactone
(+/-)-5-Hydroxydecanoic acid lactone
(+/-)-δ-Decalactone
(RS)-δ-Decalactone
δ-Amyl-δ-valerolactone
Decanoic acid, 5-hydroxy-, δ-lactone
Capric acid, δ-hydroxy-, lactone
5-Hydroxydecanoic acid δ-lactone
δ-Decanolactone
(+/-)-δ-Decanolactone
δ-Decane lactone
5-17-09-00090
5-Amyl-5-hydroxypentanoic acid lactone
Amyl-delta-valerolactone
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182189
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
DELTA-DECALACTONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Delta-Decalactone allowed in the EU?
Delta-Decalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Decalactone do in cosmetics?
Delta-Decalactone functions as: Fragrance ingredient with creamy, peach, and coconut notes. It is classified as a cosmetic ingredient in our database. CAS number: 705-86-2.
What is the NOAEL for Delta-Decalactone?
The NOAEL (No Observed Adverse Effect Level) for Delta-Decalactone is 250 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 2 study endpoints are available. Source: COSMOS DB.
Is Delta-Decalactone used outside cosmetics?
Delta-Decalactone also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Delta-Decalactone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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