Good Cosmetic Ingredient NOAEL Data

Delta-Decalactone

INCI: DELTA-DECALACTONE

CAS Number
705-86-2
Function
Fragrance ingredient with creamy, peach, and coconut notes
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under FEMA GRAS 2361; listed under 21 CFR 172.515 as a food flavoring

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Delta-Decalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 250 mg/kg bw/day oral dog Subchronic COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 250 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

No significant safety flags at current use levels; not expected to be phototoxic based on UV spectra analysis.

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Concern Level: Low

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Delta-Decalactone safe in cosmetics?

No significant safety flags at current use levels; not expected to be phototoxic based on UV spectra analysis. The EU classifies Delta-Decalactone as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is Delta-Decalactone allowed in the EU?

Delta-Decalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Delta-Decalactone do in cosmetics?

Delta-Decalactone functions as: Fragrance ingredient with creamy, peach, and coconut notes. It is classified as a cosmetic ingredient in our database. CAS number: 705-86-2.

What is the Margin of Safety for Delta-Decalactone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Delta-Decalactone?

The NOAEL (No Observed Adverse Effect Level) for Delta-Decalactone is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

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