Is Delta-Dodecalactone safe in cosmetics?
Delta-Dodecalactone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Delta-Dodecalactone
Also known as: delta-Dodecalactone (5-Dodecanolide), 5-Dodecanolide, 2H-Pyran-2-one, 6-heptyltetrahydro-, 5-Dodecalactone, Dodecanoic acid, 5-hydroxy-, delta-lactone (+7 more)
INCI: DELTA-DODECALACTONE
Delta-Dodecalactone (CAS 713-95-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with creamy, milky, peach-coconut note. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 713-95-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with creamy, milky, peach-coconut note
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
6-heptyloxan-2-one
InChIKey
QRPLZGZHJABGRS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 2401; 21 CFR 172.515
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Delta-Dodecalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Delta-Dodecalactone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "713-95-1", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
236
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
delta-DODECALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Delta-Dodecalactone.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
delta-Dodecalactone (5-Dodecanolide)
5-Dodecanolide
2H-Pyran-2-one, 6-heptyltetrahydro-
5-Dodecalactone
Dodecanoic acid, 5-hydroxy-, delta-lactone
Dodecanolide-1,5
EINECS 211-932-4
FEMA No. 2401
delta-Heptyl-delta-valerolactone
n-Heptyl-delta-valerolactone
5-Hydroxydodecanoic acid lactone
UNII-33DIC582TL
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4636895
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
DELTA-DODECALACTONE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Delta-Dodecalactone allowed in the EU?
Delta-Dodecalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Dodecalactone do in cosmetics?
Delta-Dodecalactone functions as: Fragrance ingredient with creamy, milky, peach-coconut note. It is classified as a cosmetic ingredient in our database. CAS number: 713-95-1.
Is Delta-Dodecalactone used outside cosmetics?
Delta-Dodecalactone also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Delta-Dodecalactone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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