Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Delta-Dodecalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant concerns. Not phototoxic. IFRA 51st Amendment: no restriction.
Regulatory Flags
Frequently Asked Questions
Is Delta-Dodecalactone safe in cosmetics?
No significant concerns. Not phototoxic. IFRA 51st Amendment: no restriction. The EU classifies Delta-Dodecalactone as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Delta-Dodecalactone allowed in the EU?
Delta-Dodecalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Dodecalactone do in cosmetics?
Delta-Dodecalactone functions as: Fragrance ingredient with creamy, milky, peach-coconut note. It is classified as a cosmetic ingredient in our database. CAS number: 713-95-1.
What is the Margin of Safety for Delta-Dodecalactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Delta-Dodecalactone?
The NOAEL (No Observed Adverse Effect Level) for Delta-Dodecalactone is 500 mg/kg bw/day based on a Multigeneration Reproductive study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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