Is Delta-Nonalactone safe in cosmetics?
Delta-Nonalactone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Delta-Nonalactone
Also known as: 5-Butyl-5-hydroxypentanoic acid lactone
INCI: DELTA-NONALACTONE
Delta-Nonalactone (CAS 3301-94-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with coconut, creamy, and lactonic notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance ingredient with coconut, creamy, and lactonic notes
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
6-butyloxan-2-one
InChIKey
PXRBWNLUQYZAAX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
EU Annex Listing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Delta-Nonalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6750 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [524] Epstein WL (1977): Reports to RIFM, 21 March and 31 May, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
230
Source: WHO/JECFA
JECFA Evaluation
delta-NONALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
JECFA Evaluation
HYDROXYNONANOIC ACID delta-LACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Delta-Nonalactone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
5-Butyl-5-hydroxypentanoic acid lactone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
HYDROXYNONANOIC ACID, DELTA-LACTONE
Food Category
flavoring
Frequently Asked Questions
Is Delta-Nonalactone allowed in the EU?
Delta-Nonalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Nonalactone do in cosmetics?
Delta-Nonalactone functions as: Fragrance ingredient with coconut, creamy, and lactonic notes. It is classified as a cosmetic ingredient in our database. CAS number: 3301-94-8.
Is Delta-Nonalactone used outside cosmetics?
Delta-Nonalactone also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Delta-Nonalactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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