Is Demethoxycurcumin safe in cosmetics?
Demethoxycurcumin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Demethoxycurcumin
Also known as: 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-, (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione, 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (E,E)-, 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(p-hydroxyphenyl)-, (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione (+4 more)
INCI: DEMETHOXYCURCUMIN
Demethoxycurcumin (CAS 22608-11-3) is a cosmetic cosmetic ingredient functioning as Antioxidant / skin conditioning agent (curcuminoid). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22608-11-3 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant / skin conditioning agent (curcuminoid)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
InChIKey
HJTVQHVGMGKONQ-LUZURFALSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; curcuminoids generally recognized in cosmetic formulations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Demethoxycurcumin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Speci…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Demethoxycurcumin.
Known Synonyms
1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-
(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (E,E)-
1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(p-hydroxyphenyl)-
(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
(1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Curcumin II
Desmethoxycurcumin
Monodemethoxycurcumin
Chemical Function
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL105360
Frequently Asked Questions
Is Demethoxycurcumin allowed in the EU?
Demethoxycurcumin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Demethoxycurcumin do in cosmetics?
Demethoxycurcumin functions as: Antioxidant / skin conditioning agent (curcuminoid). It is classified as a cosmetic ingredient in our database. CAS number: 22608-11-3.
Is Demethoxycurcumin used outside cosmetics?
Demethoxycurcumin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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