Deoxycholic Acid

INCI: DEOXYCHOLIC ACID

CAS Number
83-44-3
Function
Surfactant, emulsifier, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics โ€” not restricted under 21 CFR; FDA-approved as injectable drug (Kybella/ATX-101) for submental fat reduction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cytolytic at concentrations > 0.5โ€“1% causing cell membrane disruption; irritant to skin and mucous membranes per SDS data; concentration must be carefully controlled in cosmetic formulation; CPSR assessor will need concentration-specific irritation and cytotoxicity data

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Concern Level: High

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Deoxycholic Acid safe in cosmetics?

Cytolytic at concentrations > 0.5โ€“1% causing cell membrane disruption; irritant to skin and mucous membranes per SDS data; concentration must be carefully controlled in cosmetic formulation; CPSR assessor will need concentration-specific irritation and cytotoxicity data The EU classifies Deoxycholic Acid as "prohibited". Safety rating: MODERATE.

Is Deoxycholic Acid allowed in the EU?

Deoxycholic Acid EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Deoxycholic Acid do in cosmetics?

Deoxycholic Acid functions as: Surfactant, emulsifier, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 83-44-3.

What is the Margin of Safety for Deoxycholic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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