Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diethyl Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 48.3 other | dermal | code:3543 | dermal | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Volatile organic solvent with flash point ~25°C (flammable); eye and respiratory irritant at higher concentrations. Widely used as industrial solvent but cosmetic use-level safety data is limited. Inhalation exposure must be assessed for spray/aerosol products.
Frequently Asked Questions
Is Diethyl Carbonate safe in cosmetics?
Volatile organic solvent with flash point ~25°C (flammable); eye and respiratory irritant at higher concentrations. Widely used as industrial solvent but cosmetic use-level safety data is limited. Inhalation exposure must be assessed for spray/aerosol products. The EU classifies Diethyl Carbonate as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Diethyl Carbonate allowed in the EU?
Diethyl Carbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Carbonate do in cosmetics?
Diethyl Carbonate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-58-8.
What is the Margin of Safety for Diethyl Carbonate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Carbonate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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