NOAEL Studies
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Diethylamino Hydroxybenzoyl Hexyl Benzoate NOAEL Studies
INCI: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE
CAS: 302776-68-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 1000 | mg/kg bw/day | rat | oral | 6-19 Gestation day | Developmental | SCCP; Schilling K., H et al. (4-Diethylamino-2-hydroxybenzoyl)-benzoesaurehexylester- Prenatal Developmental Toxicity Study in Wistar Rats, Oral Administration Gavage).Project 30R0408/99112. BASF AG Product Safety Regulations Tox and Ecology |
| COSMOS DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 6-19 Gestation day | Developmental | SCCP; Schilling K., H et al. (4-Diethylamino-2-hydroxybenzoyl)-benzoesaurehexylester- Prenatal Developmental Toxicity Study in Wistar Rats, Oral Administration Gavage).Project 30R0408/99112. BASF AG Product Safety Regulations Tox and Ecology |
SCCNFP Opinion 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =0.1 | µg/cm | rat | oral | 90-day | dermal absorption | p.15 |
| SCCNFP Opinion | NOAEL | =200 | mg/kg bw/day | - | oral | prenatal | developmental toxicity | Ref. : 12 2, p.8 |
| SCCNFP Opinion | NOAEL | =200 | mg/kg | rat | oral | - | NOAEL study | p.15 |
| SCCNFP Opinion | NOAEL | >1000 | mg/kg bw/day | pig | oral | prenatal | developmental toxicity | Ref. : 12 2, p.8 |
| SCCNFP Opinion | NOAEL | >1000 | mg/kg bw | rat | oral | 90-day | dermal absorption | Ref. : 9 2, p.14 |
| SCCNFP Opinion | NOAEL | =1350 | mg/kg bw | rat | oral | 90-day | NOAEL study | Ref. : 9 2, p.14 |
| SCCNFP Opinion | NOAEL | =2000 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.15 |
| SCCNFP Opinion | NOAEL | =3000 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | Ref. : 11 2, p.6 |
| SCCNFP Opinion | NOAEL | =15000 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | Ref. : 11 2, p.6 |
SCCS Opinion 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =-1 | - | rat | - | - | reproductive toxicity | Ref: Furr 2014), p.14 |
| SCCS Opinion | NOAEL | =0.025 | mg/kg bw/d | - | oral | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =0.09 | mg/kg bw/d | rat | oral | - | dermal absorption | p.23 |
| SCCS Opinion | NOAEL | =0.093 | mg/kg | rat | oral | 90-day | developmental toxicity | p.20 |
| SCCS Opinion | NOAEL | =2.5 | mg/kg bw/d | - | oral | 1 year | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/d | rat | oral | Prenatal | reproductive toxicity | p.13 |
| SCCS Opinion | NOAEL | =18 | - | rat | - | - | reproductive toxicity | Ref: Furr 2014), p.14 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/day | - | - | - | repeated dose toxicity | p.15 |
| SCCS Opinion | NOAEL | =50 | % | - | oral | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.15 |
| SCCS Opinion | NOAEL | =200 | mg/kg | rat | oral | 90-day | developmental toxicity | p.20 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | - | oral | prenatal | developmental toxicity | p.18 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw | rat | oral | - | dermal absorption | p.23 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | rat | oral | 35-day | reproductive toxicity | Ref: Saillenfait 2009) 3, p.14 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.15 |
| SCCS Opinion | NOAEL | =2000 | mg/kg bw | rat | oral | 90-day | developmental toxicity | p.20 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | - | Chronic | reproductive toxicity | p.12 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | - | - | reproductive toxicity | p.14 |
| SCCS Opinion | NOAEL | =15000 | ppm | rat | - | Chronic | reproductive toxicity | p.12 |
| SCCS Opinion | NOAEL | =15000 | ppm | rat | - | - | reproductive toxicity | p.14 |
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b80ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29413?documentUUID=31971d96-ae18-48a4-a10c-892a4a9f3930; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855652_15856427:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3dbe25eed28aa0b43a80da29ee52e404 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd610; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29413?documentUUID=31971d96-ae18-48a4-a10c-892a4a9f3930; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15823099:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd0871082086d09f32904ea0e4fa5913 |
| ECHA | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b80ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29413?documentUUID=31971d96-ae18-48a4-a10c-892a4a9f3930; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855652_15856427:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c869cfb789e5f09c5bb946d39684d6ec |
| ECHA | NOAEL | >=1000 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd610; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29413?documentUUID=31971d96-ae18-48a4-a10c-892a4a9f3930; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15821819:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ae3ec106169c53dd08165876df6d74c |
| ECHA | NOAEL | >=1440 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae13e4b0a7c65d1c74c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/29413?documentUUID=31971d96-ae18-48a4-a10c-892a4a9f3930; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15834947:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af3fd1a85eaec94c9bb54c2424d0791e |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632559:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c2867803bb589c7ef4e2799f243bed4 |
Regulatory source 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 200 | mg/kg | rat | oral | - | - | p.15 |
| Regulatory source | - | 1350 | mg/kg bw | rat | oral | 90-day | - | p.14 |
| Regulatory source | dermal absorption | 0.1 | µg/cm | rat | oral | 90-day | dermal absorption | p.15 |
| Regulatory source | dermal absorption | >1000 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.14 |
| Regulatory source | dermal absorption | 1350 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.15 |
| Regulatory source | dermal absorption | 2000 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.15 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/day | - | oral | prenatal | developmental toxicity | p.8 |
| Regulatory source | developmental toxicity | >1000 | mg/kg bw/day | pig | oral | prenatal | developmental toxicity | p.8 |
| Regulatory source | developmental toxicity | >1000 | mg/kg bw/day | - | oral | prenatal | developmental toxicity | p.8 |
| Regulatory source | repeated dose toxicity | 3000 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | p.6 |
| Regulatory source | repeated dose toxicity | 15000 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | p.6 |
| Regulatory source | repeated dose toxicity | 15000 | ppm | - | dermal | Sub-chronic | repeated dose toxicity | p.6 |
| Regulatory source | dermal absorption | =0.09 | mg/kg bw/d | rat | oral | - | dermal absorption | p.23 |
| Regulatory source | dermal absorption | =200 | mg/kg bw | rat | oral | - | dermal absorption | p.23 |
| Regulatory source | developmental toxicity | =0.093 | mg/kg | rat | oral | 90-day | developmental toxicity | p.20 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.15 |
| Regulatory source | developmental toxicity | =200 | mg/kg | rat | oral | 90-day | developmental toxicity | p.20 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/d | rat | oral | 90-day | developmental toxicity | p.20 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/day | rat | oral | 90-day | developmental toxicity | p.23 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.15 |
| Regulatory source | developmental toxicity | 2000 | mg/kg bw | rat | oral | 90-day | developmental toxicity | p.20 |
| Regulatory source | reproductive toxicity | 3000 | ppm | rat | - | Chronic | reproductive toxicity | p.12 |
| Regulatory source | reproductive toxicity | 3000 | ppm | rat | - | - | reproductive toxicity | p.14 |
| Regulatory source | reproductive toxicity | 15000 | ppm | rat | - | Chronic | reproductive toxicity | p.12 |
| Regulatory source | reproductive toxicity | 15000 | ppm | rat | - | - | reproductive toxicity | p.14 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | ANQ870JD20 | UNII | - | - | - | chemical | - |